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Pharmacology > Antivirals > Flashcards

Antivirals Flashcards

1
Q

Foscarnet DOC

A

Resistance to DNA polymerase alpha & Thymidylate kinase

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2
Q

Acyclovir a/e

A

Crystalluria
Neurotoxicity
BM suppression

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3
Q

Cidofovir

use

A

DOC Recurrent laryngeal papillomatosis
BK virus
Adenovirus

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4
Q

Idoxuridin
use
a/e

A

use- HSV keratitis, VZV skin lesion, Orolabial/Genital herpes

a/e - Cardiotoxic

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5
Q

Foscarnet
MOA
use

A

MOA- inhibition of pyrophosphate binding site of DNA polymerase delta and epsilon

use- DOC resistant herpes

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6
Q

Fomivirsen
MOA
use

A

inhibits viral attachment

resistant CMV retinitis

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7
Q

Docosanol
MOA
use

A

ethanol derivative
inhibits viral attachment
use - Oro-labial herpes

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8
Q

Letermovir
MOA
Use

A

inhibits CMV DNA terminase

use- prophylaxis of CMV infection in patients of stem cell transplantation

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9
Q

Baloxavir marboxil
MOA
use

A

MOA- inhibits cap dependent endonuclease

use- uncomplicated influenza

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10
Q

Diridirumab

MOA

A

Haemagglutinin inhibitor

Anti influenza mab

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11
Q

M-protein inhibitor
MOA
drugs
a/e

A

MOA- inhibits viral uncoating
drugs - Amantadine, Rimantidine
a/e - ankle edema , livedoreticularis

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12
Q

Neuramidase inhibitors
MOA
drugs
use

A

inhibits viral release
Oseltamivir, Zanamivir (if Oseltamivir resistant)
Influenza A, B and Bird flu
C.I. in asthma, COPD

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13
Q

Peramivir

A

IV for sensitive cases of influenza

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14
Q

Laninamivir

A

inhalational ,

oseltamivir resistant cases

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15
Q

Entecavir

A

anti Hepatitis B
Most potent
Ineffective in Lamivudine resistance

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16
Q

Adefovir

A

Least effective in Hepatitis B
effective in Lamivudine resistance
poor oral absorption

17
Q

Tenofovir

DOC

A

DOC for Hepatitis B

18
Q

DOC of Hep B with Hep D

A

Interferon alpha

19
Q

Ribavirin
MOA
use

A

inhibits RNA synthesis

DOC RSV

20
Q

Rescue regimen for Hep C

A

Velpatasvir + Voxilaprevir + Sofosbuvir

21
Q

CD4 inhibitors used in HIV

A

Enfuvirtide (s/c),

Ibalizumab (iv)

22
Q

NRTIs

-ZE LADS

A 
Zidovudine
Emtricitabine
Lamivudine
Abacavir
Didanosine
Stavudine
23
Q

NNRTIs

-NEED R

A 
Nevirapine
Efavirenz
Etravirine
Delavirdine
Rilpivirine
24
Q

Zidovudine

a/e

A

BM suppression
Nail hyperpigmentation
Hepatotoxicity

25
Q

Tenofovir

a/e

A

Nephrotoxic

Fanconi syndrome

26
Q

Stavudine

a/e

A

Max peripheral neuropathy

27
Q

Didanosine

a/e

A

Pancreatitis, Heptotoxicity

28
Q

Rilpivirine

a/e

A

QT prolongation

29
Q

Nevirapine

a/e

A

Fatal hepatotoxicity

30
Q

Efavirenz

a/e

A

Teratogenic
Neuropsychiatric effect
Gynecomastia

31
Q

A/E
Rolutegravir
Dolutegravir

A

both- Hepatotoxic, SJS

/Rolute- Rhabdomyolysis

32
Q

Protease inhibitors

a/e

A

DM,
Dyslipidemia (DOC- Pravastatin),
Fat deposition (buffalo hump)

33
Q

Indinavir

a/e

A

Crystalluria

34
Q

Tripranavir

a/e

A

intracranial haemorrhage

Pharmacology (8 decks)

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