Neurology

Question 1

Cenobamate

Answer 1

Treatment of partial onset seizures in adults with epilepsy

Question 2

DOC for Jacksonian march with Todd’s palsy

Answer 2

Carbamazepine i.e. DOC for focal seizure

Question 3

Duchenne MD amenable for Exon 45 skipping

Answer 3

Rx Casimersen

Question 4

Duchenne MD with confirmed gene mutation

Answer 4

Rx Viltolarsen

Question 5

DOC in GTCS

Answer 5

CCB like Valproate

Question 6

Partial seizure DOC

Answer 6

Na channel blocker -> Carbamazepine

also DOC in neuropathic pain

Question 7

Valproate MOA

Answer 7

1. CCB
2. Na channel blocker
3. decreases GABA
4. Inhibits histone deacetylase

Question 8

Valproate DOC in

Answer 8

1. GTCS
2. Myoclonic seizures
3. Absence seizures
4. Lennox gastaut syndrome
5. Rapid cyclers
6. Rheumatic chorea
7. Acute mania and prophylaxis of migraine
8. Dravet syndrome

Question 9

Antiepileptics causing fulminant hepatitis

Answer 9

Valproate and Phenytoin

Question 10

Antiepileptics that are folate antagonists

Answer 10

Phenytoin and Phenobarbitone

Question 11

Ethosuximide
MOA
DOC
A/E

Answer 11

• CCB
• Absence seizures in <2 years of age
• Vomiting(MC), Neurotoxicity, BM suppression, SLE

Question 12

Phenytoin

MOA

Answer 12

Prolongation of Na+ channel inactivation

Question 13

Antimicrobials causing seizures

“BAG IQ”

Answer 13

B- Beta lactams
A- Acyclovir
G- Ganciclovir
I- Isoniazid
Q- Quinolones

Question 14

DOC Prophylaxis of MIgraine

Answer 14

Propranolol > Topiramate

Question 15

Zonisamide
MOA
use
A/E

Answer 15

MOA- NCB, CCB, free radical scavenger
use- partial seizures
a/e- CA inhibitor

Question 16

Rufinamide
MOA
use
A/E

Answer 16

moa-NCB
use- LGS
a/e- QT shortening, Leucopenia

Question 17

Lacosamide
MOA
source
use
A/E

Answer 17

moa- SLOW activation, NCB
source- amino acid L serine
use- Partial seizure
a/e- Prolonged PR interval, Suicidal tendency

Question 18

Ezogabine/ Retigabine
MOA
A/E

Answer 18

moa- K+ channel opener
a/e- Pigmentation of skin, lip, nails.
tremors,
retinal deposits

Question 19

Felbamate
MOA
use
A/E

Answer 19

NMDA*R blocker
use - GTCS, Parital seizures.
A/E- BM suppression, Hepatotoxicity

Question 20

Perampanel, Talampanel
MOA
use
A/E

Answer 20

AMPA antagonist
use - partial agonist
a/e- somnolence , mood abnormality

Question 21

GABA A agonists

Answer 21

BZD, barbiturates, Ganaxolone, Stiripentol