Gen + Alkylating agents

Question 1

5-HT3 inhibitors

-drugs

Answer 1

/Ondansetron -most specific (DOC)

/Palonosetron - long acting , late onset vomiting

Question 2

NK1 inhibitors

Answer 2

Aprepitant - DOC for late onset nausea and vomiting

Question 3

Cyclophosphamide

• use
• a/e

Answer 3

DOC - Wegener’s granulomatosis, Steroid dependent nephrotic syndrome.
-RA, IBD

women- breast, ovarian cancer
paeds- Wilms tumour, Neuroblastoma
bone- NHL, CLL

-a/e - Hemorrhagic cystitis (acrolein), SIADH (chloroacetaldehyde)

Question 4

Ifosfamide

• MOA
• use
• a/e

Answer 4

• alkylating agent
• Osteosarcoma, testicular carcinoma
• Most neurotoxic alkylating agent, hemorrhagic cystitis

Question 5

Mechlorethamine

• MOA
• use
• a/e

Answer 5

• alkylating agent
• Hodgkins lymphoma (MOPP - old)
• a/e - Vesication

Question 6

Melphalan

• MOA
• use

Answer 6

• alkylating agent

- Multiple Myeloma (Lenalidomide, Bortezomib, Dexamethasone)

Question 7

Chlorambucil

• MOA
• use

Answer 7

• alkylating agent

- CLL

Question 8

Bendamustine

• MOA
• use

Answer 8

• alkylating agent (similar to chlorambucil)

- CLL, Hodgkins lymphoma

Question 9

Nitrosoureas

• drugs
• use
• a/e

Answer 9

/Carmustine, Lomustine, Semustine -for Brain tumour
-a/e - Neutropenia

/Streptozocin- for pancreatic CA, Malignant carcinoid tumour

Question 10

DNA methylaters

• drugs
• use
• a/e

Answer 10

/Procarbazine - Hodgkin’s disease
-a/e - Disulfiram like reaction, Cheese reaction , Serotonin syndrome.

/Dacarbazine - Hodgkins lymphoma

/Temazolamide - DOC brain tumour (GBM)

Question 11

Busulfan
use
a/e

Answer 11

• CML

- a/e - pulmonary fibrosis, veno occlusive hepatic disease.

Question 12

Resistant ovarian CA

Answer 12

-Thiotepa , Altretamine, Trabectadin