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Pharmacology > Protein Synthesis Inhibitors II > Flashcards

Protein Synthesis Inhibitors II Flashcards

1
Q

Fusidic acid

  1. Type of antibiotic
  2. MOA
  3. Admin + Adjunct
    4.Indications
A
  1. Steriod antibiotic
  2. Similar to macrolides(50s) -inhibts translocation
  3. Taken with food(orally) and topically-acute skin infections(5days) and conjunctive
  4. Severe staphylococcal infections
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2
Q

Min days for topical admin for fusidic acid

A

5 days

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3
Q

Fusidic acid S/E and extra info-4?

A
  1. Hepatotoxicity (Reversible)
  2. Kernicterus
  3. GIT effects(take with meals)
  4. IM-Local tissue necrosis
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4
Q

Fusidic acid DI?

A
  1. Hydrocortisone (Decreased antibiotic activity of fuisdic acid)
  2. Statins (Increased risk of rhabdomyolysis)
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5
Q

Fusidic acid CI?

A

Hepatic dysfunction & pregnancy

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6
Q

Mupirocin 3 MOA?

A

Inhibits:

  1. Protein synthesis
  2. DNA & RNA synthesis
  3. Cell wall synthesis
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7
Q

Mupirocin

  1. Bacteria MOA
  2. Admin
  3. Type of bacteria
A
  1. Bactericidal
  2. Topical only(no systemic absorption)
  3. Gram +ve bacteria
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8
Q

Mupirocin preparations?

A

Preparations contain polyethylene glycol=may lead to toxicity

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9
Q

Mupirocin and Methicillin bacteria?

A

Methicillin-resistant staph aureus

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10
Q

Mupirocin S/E?

A

-Burning
-Mild stinging
-Itching at site of application

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11
Q

Mupirocin caution?

A

Porphyria

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12
Q

Ketolides CYP450?

A

CYP450 Inhibitors

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13
Q

Ketolides MOA?

A

-Similiar effects as macrolides-Inhibit 50s

-Also inhibits the formation of new ribosomes

-Binds to two sites on the bacterial ribosome with higher affinity than macrolides

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14
Q

Ketolides derivative?

A

Semi-synthetic derivatives of Erthromycin A-Telithromycin

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15
Q

Ketolides dosage frequency and max days of admin?

A

Once daily dosage(5 days)

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16
Q

Ketolides S/E-4?

A
  1. Respiratory failure (Myasthenia gravis patients)
  2. Hepatotoxicity
  3. Visual disturbances
  4. Loss of consciousness
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17
Q

Oxazolidinones type of antibiotic?

A

Linezolid-reversible non-selective MOA

18
Q

Oxazolidinones resolution rank in antibiotic therapy?

A

Last resort where every other therapy has failed-Should be reserved for only that purpose

19
Q

Oxazolidinones MOA(2)?

A
  1. Prevents formation of ribosome complex
  2. Binds to 235 ribosmal RNA of the 50s ribosomal subunit
20
Q

Oxazolidinones admin & bioavailability ?

A

IV/Oral(100% bioavailability)

21
Q

Oxazolidinones resistance?

A

-Mutation of linezolid binding site on 235 ribosomal RNA

22
Q

Oxazolidinones S/E?

A
  1. Moniliasis/Fungal infection
  2. Metallic taste
  3. Peripheral neuropathy & neurotoxicity
  4. Haemolytic toxicty
23
Q

Oxazolidinones DI?

A

SNS agonist or adrenergic drugs can cause serotonin syndrome

24
Q

Streptogramins & CYP450?

A

CYP450 Inhibitor

25
Q

Streptogramins composition/ratio?

A

Quinupristin-Dalfopristin

(Fixed 30/70 combination)

26
Q

Streptogramins derivative?

A

Semi-synthetic derivatives of pristinamycin

27
Q

Streptogramins classes?

A

Macrolide/ Lincosamide/ Streptogramin class

28
Q

Streptogramins MOA-4?

A
  1. Two components are structurally unrelated
  2. Bind to distinict sites on the 50S ribsomal subunit

3.Interfere with peptidyl transferase enzyme action

4.They cooperate to inhibit protein synthesis

29
Q

Streptogramins admin?

A

IV administration

30
Q

Streptogramins S/E?

A
  1. Arthralgia
  2. Myalgia
  3. Conj Hyperbilirubinaemia
  4. Asthenia
    Inflammation
  5. Oedema, Thrombophlebitis-Via Peripheral Vein
    6
31
Q

Streptogramins resistance-2?

A
  1. Quinupristin
    -A ribosomal methylase that prevents bindIng
    -Lactonases produced that inactiavte the drug
  2. Dalfopristin
    - Acetyltransferases
    produced that
    inactivate the drug
    -Increased efflux
32
Q

Streptogramins resistance-2?

A
  1. Quinupristin
    -A ribosomal methylase that prevents bindIng
    -Lactonases produced that inactiavte the drug
  2. Dalfopristin
    - Acetyltransferases
    produced that
    inactivate the drug
    -Increased efflux
33
Q

Lipopeptides type of drug & bacteria

A

Daptomycin(IV)

Bactericidal

34
Q

Lipopeptides MOA?

A
  1. Inhibition of protein, DNA & RNA synthesis
  2. Disrupts bacterial cell membrane function
  3. Binds to the membrane and cause rapid depolarisation
  4. Cause a loss of membrane potential
35
Q

Lipopeptides S/E-7?

A
  1. Myopathy & Rhabdomyolsis (with statins)
  2. Acute renal failure
  3. Dyspnea
  4. Electrolyte disturbances
  5. CVS & CNS effects

6.Haematological effects

  1. Hepatic effects
  2. Musculoskeletal effects
36
Q

Disruption of bacterial plasma membrane?

A

Polymyxin B & E(colistin)- positive charged peptides

37
Q

Disruption of bacterial plasma MOA?

A
  1. Attach to phospholipids in bacterial plasma membrane-disrupt
  2. Change membrane permeability
38
Q

Disruption of bacterial plasma membrane S/E?

A
  1. Nephrotoxic
  2. Neurotoxic
39
Q

Polymyxin E(Colistin) Admin

A

-IV

-Unlicenced

40
Q

Polymyxin E(Colistin) I?

A

-Severe resistant gram -ve infections (Carbapenems resistant)

-Last line treatment for multi-drug resistant infections

41
Q

Polymyxin E(Colistin) S/E?

A

Nephrotoxicity
(Reversible)

Pharmacology (44 decks)

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