Protein Synthesis Inhibitors Flashcards
Aminoglycosides
Clinical Use
Severe Gram - aerobes
Neomycin enema for bowel surgery
Tetracyclines
Clinical Use
VACUUM THe BedRoom
Vibrio cholerae, Acne, Chlamydia, Ureplasma, Urelytica, Mycoplasma Pneumonia, Tuluremia, H. Pylori, Borellia Burgdorferi, Rickettsia
Chloramphenicol
Clinical Use
Meningitis (crosses BBB)
Rickettsia in children
Clindamycin
Clinical Use
Gram + anaerobes above the diaphragm
Macrolides
Clinical Use
URI, pneumonia, STIs, Conunctivitis
Linezolid
Clinical Use
Hospital acquired pneumonia
S. Aureus pneumonia
MRSA and VRE
Streptogramins
Clinical Use
Bacteremia from VRE
Enterococcus Faceium
VRSA skin infections
Mupirocin
Clinical Use
BS g+ and g- topical for skin infections
MRSA and MRSP
Aminoglycosides
Toxicity
Nephrotoxicity
Ototoxicity
Teratogenic
Tetracyclines
Toxicity and contraindications
Headache Metallic Taste Hairy Tongue Enamel discoloration and weakness Don't give with alcohol, divalent cations, or to pregnant women
Chloramphenicol
Toxicity
Anemia Hemolytic anemia Aplastic anemia Grey baby syndrome (Conservatively used due to toxicity)
Clindamycin
Toxicity
C. Difficile overgrowth Hematologic problems Fever Diarrhea Cellulitis
Macrolides
Toxicity
Safest of all antimicrobials
PIG EAR
Prolonged QT, Increased serum theophyllines, GI discomfort, Eosinophilia, Acute Cholestatic Hepatitis, Rash
Linezolid
Toxicity
Bone Marrow Suppression Avoid if on MOA suppressors Headache GI disturbance Reversible neurotoxicity
Streptogramins
Toxicity
Hyperbilirubinemia
Injection site pain and inflammation
Myalgia and Arthralgia
Mupirocin
Toxicity
Injection site pain and inflammation
Aminoglycosides
Mechanism
Bactericidal
30s subunit
Inhibits initiation, induces misreading, forces early termination
Tetracyclines
Mechanism
Bacteriostatic
30s subunit
Doesn’t allow binding of aminoacyl tRNA
Chloramphenicol
Mechanism
Bacteriostatic
50s subunit
Prevents peptidyltranferase reaction
Clindamycin
Mechanism
Bacteriostatic
50s subunit
Blocks peptide bond formation
Macrolides
Mechanism
Bacteriostatic
50s subunit
Inhibits translocation
Linezolid
Mechanism
Bacteriostatic
50s subunit
Streptogramins
Mechanism
Bacteriostatic
50s subunit
Mupirocin
Mechanism
Bactericidal
Inhibits isoleucyl tRNA synthetase
What is the broadest spectrum aminoglycoside?
Amikacin
Which antibiotic is fecaly eliminated?
Doxycycline
Which protein synthesis inhibitor crosses the BBB?
Chloramphenicol
Which PSI is absorbed well orally?
Macrolides
Which PSI is only give IV?
Streptogramins
What should you avoid with mupirocin?
Large coverage of skin areas in patients with renal insufficiency.
