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Antibiotics > Protein Synthesis Inhibitors > Flashcards

Protein Synthesis Inhibitors Flashcards

1
Q

Aminoglycosides

Clinical Use

A

Severe Gram - aerobes

Neomycin enema for bowel surgery

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2
Q

Tetracyclines

Clinical Use

A

VACUUM THe BedRoom
Vibrio cholerae, Acne, Chlamydia, Ureplasma, Urelytica, Mycoplasma Pneumonia, Tuluremia, H. Pylori, Borellia Burgdorferi, Rickettsia

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3
Q

Chloramphenicol

Clinical Use

A

Meningitis (crosses BBB)

Rickettsia in children

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4
Q

Clindamycin

Clinical Use

A

Gram + anaerobes above the diaphragm

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5
Q

Macrolides

Clinical Use

A

URI, pneumonia, STIs, Conunctivitis

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6
Q

Linezolid

Clinical Use

A

Hospital acquired pneumonia
S. Aureus pneumonia
MRSA and VRE

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7
Q

Streptogramins

Clinical Use

A

Bacteremia from VRE
Enterococcus Faceium
VRSA skin infections

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8
Q

Mupirocin

Clinical Use

A

BS g+ and g- topical for skin infections

MRSA and MRSP

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9
Q

Aminoglycosides

Toxicity

A

Nephrotoxicity
Ototoxicity
Teratogenic

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10
Q

Tetracyclines

Toxicity and contraindications

A 
Headache
Metallic Taste
Hairy Tongue
Enamel discoloration and weakness
Don't give with alcohol, divalent cations, or to pregnant women
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11
Q

Chloramphenicol

Toxicity

A 
Anemia
Hemolytic anemia
Aplastic anemia
Grey baby syndrome
(Conservatively used due to toxicity)
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12
Q

Clindamycin

Toxicity

A 
C. Difficile overgrowth
Hematologic problems
Fever
Diarrhea
Cellulitis
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13
Q

Macrolides

Toxicity

A

Safest of all antimicrobials
PIG EAR
Prolonged QT, Increased serum theophyllines, GI discomfort, Eosinophilia, Acute Cholestatic Hepatitis, Rash

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14
Q

Linezolid

Toxicity

A 
Bone Marrow Suppression
Avoid if on MOA suppressors
Headache
GI disturbance
Reversible neurotoxicity
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15
Q

Streptogramins

Toxicity

A

Hyperbilirubinemia
Injection site pain and inflammation
Myalgia and Arthralgia

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16
Q

Mupirocin

Toxicity

A

Injection site pain and inflammation

17
Q

Aminoglycosides

Mechanism

A

Bactericidal
30s subunit
Inhibits initiation, induces misreading, forces early termination

18
Q

Tetracyclines

Mechanism

A

Bacteriostatic
30s subunit
Doesn’t allow binding of aminoacyl tRNA

19
Q

Chloramphenicol

Mechanism

A

Bacteriostatic
50s subunit
Prevents peptidyltranferase reaction

20
Q

Clindamycin

Mechanism

A

Bacteriostatic
50s subunit
Blocks peptide bond formation

21
Q

Macrolides

Mechanism

A

Bacteriostatic
50s subunit
Inhibits translocation

22
Q

Linezolid

Mechanism

A

Bacteriostatic

50s subunit

23
Q

Streptogramins

Mechanism

A

Bacteriostatic

50s subunit

24
Q

Mupirocin

Mechanism

A

Bactericidal

Inhibits isoleucyl tRNA synthetase

25
Q

What is the broadest spectrum aminoglycoside?

A

Amikacin

26
Q

Which antibiotic is fecaly eliminated?

A

Doxycycline

27
Q

Which protein synthesis inhibitor crosses the BBB?

A

Chloramphenicol

28
Q

Which PSI is absorbed well orally?

A

Macrolides

29
Q

Which PSI is only give IV?

A

Streptogramins

30
Q

What should you avoid with mupirocin?

A

Large coverage of skin areas in patients with renal insufficiency.

Antibiotics (5 decks)

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