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Antibiotics > Antifungals > Flashcards

Antifungals Flashcards

1
Q

Nystatin

Mechanism

A

Binds ergosterol -> forms pores -> K+ leaks

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2
Q

Azoles

Mechanism

A

Inhibits ergosterol synth via CYP450 dependent enzyme lanosterol 14- alpha-demethylase

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3
Q

Flucytosine

Mechanism

A

Inhibits DNA and RNA synth

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4
Q

Caspofungin

Mechanism

A

Inhibits cell wall synthesis by blocking beta glucan synth

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5
Q

Terbinafine

Mechanism

A

Inhibits fungal enzyme squalene epoxidase

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6
Q

Griseofulvin

Mechanism

A

Interferes with microtubule function

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7
Q

Amphotericin B

Clinical use

A

Systemic of local candidemia

Aspergillus

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8
Q

Nystatin

Clinical Use

A 
Oral Candida albicans (mouth wash)
Vaginal candidiasis (cream)
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9
Q

Azoles

Clinical Use

A

Fluconazole- Cryptococcal meningitis in AIDS and c albicans
Ketoconazole- systemic, or topical therapy
Clotrimazole & Miconazole - topical
Vorconizole- 1st line for aspergillosis

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10
Q

Flucytosine

Clinical Use

A

Systemic fungal infections

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11
Q

Caspofungin

Clinical Use

A

Fungicidal candida species and invasevie aspergillosis

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12
Q

Terbinafine

Clinical Use

A

Dermatophytes (onychomycosis), mucocutaneous fungal infections

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13
Q

Griseofulvin

Clinical Use

A

Inhibits growth of dermatophytes

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14
Q

Amphotericin B

Toxicity

A

Fever and chills
Hypotension
Nephrotoxicity
Neurotoxicity

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15
Q

Nystatin

Toxicity

A

Headache
Metallic taste
Disulfiram like reaction
(Too toxic to give orally)

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16
Q

Azoles

Toxicity

A

Gynecomastia
Hypercortisolism
Liver dysfunction
Fever chills

17
Q

Flucytosine

Toxicity

A

Nausea
Vomiting
Diarrhea
Bone Marrow Suppression

18
Q

Caspofungin

Toxicity

A

GI upset

Flushing

19
Q

Terbinafine

Toxicity

A

Hepatotoxicity
Visual Disturbance
Hematologic disorders
Cellulitis

20
Q

Griseofulvin

Toxicity

A

Teratogenic
Carcinogenic
Headaches

21
Q

Which two antifungals are synergistic and what are they used in combo for?

A

Amphotericin B and Flucytosine for cryptococcal meningitis

22
Q

Which antifungal induces CYP450 warfarin metabolism and which inhibits CYP450?

A

Griseofulvin induce and azoles inhibit

23
Q

Amphotericin B

Mechanism

A

Binds ergosterol -> forms pores -> K+ leaks

Antibiotics (5 decks)

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