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Antibiotics > Cell Wall Inhibitors > Flashcards

Cell Wall Inhibitors Flashcards

1
Q

Natural Penecillins

Clinical Use

A

Common streptococci, pneumocci, enterocci, meningococci, treponema pallidum

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2
Q

Natural Penecillins

Toxicity

A

Hypersensitivity
Hemolytic Anemia
Cross Sensitive

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3
Q

Penecillinase Resistant Penecillins

A

Nafcillin, Methicillin, Dicloxacillin

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4
Q

Penecillinase Resistant Penecillins

Mechanism

A

Same as Penecillins

Narrow spec

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5
Q

Penecillinase Resistant Penecillins

Clinical Use

A

Staphylococcus (naf for staph)

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6
Q

Penecillinase Resistant Penecillins

Toxicity

A

Headache

Metallic Taste

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7
Q

Aminopenecillins

A

Amoxicillin

Ampicillin

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8
Q

Amino penicillins

Mechanism

A

Same as pen.

Broad spec with clavulanate

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9
Q

Aminopenecillins

Clinical Use

A

Broad spec

DOC for Listeria monocytogenes, enterocci, and prophy for infective endocarditis

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10
Q

Amino penicillins

Toxicity

A

Hypersensitivity
Ampicillin Rash
Pseudo membranous colitis

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11
Q

Anti-pseudomonal Penecillins

A

Piperacillin
Ticarcillin
CarbenIcillin

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12
Q

Anti-pseudomonas Penecillins

Mechanism

A

Same as pen

Extended spec

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13
Q

Anti-pseudomonas Penecillins

Clinical use

A

Pseudomonas and gram - rods

Synergy with aminoglycoside so

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14
Q

Anti pseudomonal Penecillins

Toxicity

A

Hypersensitivity

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15
Q

Cephalosporins

Mechanism

A

Penacillinase resistant

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16
Q

Cephalasporins

Clinical Use

A

1st gen - PEK (proteus miribalis, E. coli, klebsiella pneum.)
2nd gen - HENPEKS (H. Influenza, Enterobacter aerogels, neisseria, same 3, Seratia)
3rd gen - gram+/- cocci, gram - rod, meningitis (crosses BBB), anaerobes, gonococci, pseudomonas
4th gen - pseudomonas
5th gen - covers MRSA

17
Q

Cephalasporins

Toxicity

A

Hypersensitivity
Increases toxicity of aminoglycosides
Pseudo membranous colitis

18
Q

Aztreonam
(Monobactam)
Mechanism

A

Same as pen. But binds to PBP-3
Penecillinase resistant
Renally excreted

19
Q

Monobactam

Clinical use

A

Gram - Aerobes

(SPiKe) Seratia, Pseudomonas, Klebsiella

20
Q

Monobactam

Toxicity

A 
Pseudomembranous Colitis
Hematological disorders
Fever
Diahrrea 
Cellulitis
21
Q

Carbapenems

Mechanism

A

Same as pen.
Broad spec
Penecillinase resistant

22
Q

Carbapenems

Clinical use

A

+ cocci, - rods

DOC for enterobacteria

23
Q

Carbapenems

Toxicity

A

CNS toxicity
GI
Skin rash
Skeletal muscle toxicity

24
Q

Vancomycin

Mechanism

A

Inhibits cell wall formation by binding d-ala d-ala

25
Q

Vancomycin

Clinical Use

A

Multidrug resistant gram +

Staph aureus, Clostridium difficile

26
Q

Vancomycin

Toxicity

A

Nephrotoxicity
Ototoxicity
Thrombophlebitis
Red Man Syndrome

27
Q

Bacitracin

Mechanism

A

Blocks peptidoglycan synthesis

28
Q

Bacitracin

Clinical use

A

Topical Antimicrobial

29
Q

Bacitracin

Toxicity

A

Nephrotoxicity

Ototoxicity

30
Q

Daptomycin

Mechanism

A

Inserts into cell membrane and forms ion channels

31
Q

Daptomycin

Clinical Use

A

Vanc and Meth resistant gram +

32
Q

Daptomycin

Toxicity

A

headache
GI
insomnia
Rhabdomyalasis

33
Q

Beta-lactamase inhibitor/drug combos

A

Augmentin - Amoxicillin and Clavulanate
Unycin - Ampicillin and Sublactam
Zosyn - Pipercillin and Tazobactam

34
Q

What is the broadest spectrum antibacterial?

A

Imipenem

35
Q

What must you administer with Imipenem and why?

A

Cilistatin - inhibits renal dihydropeptidase 1

36
Q

Which amino penecillin is administered orally?

A

Amoxicillin

37
Q

Natural Penecillins

Mechanism

A 
Bactericidal
Inhibits transpeptidase (PBP)
Activates autolysins

Antibiotics (5 decks)

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