Protein Synthesis Inhibitors Flashcards
What category of drug are tetracyclines?
protein synthesis inhibitor
MOA of tetracyclines
bind to 30S subunit
With what drug are dairy, antacids and iron supplements contraindicated?
tetracyclines
except doxycycline
Which tetracycline attains good CSF levels and enters the brain?
minocycline
Where are tetracyclines metabolized?
liver - goes through phase 2
What drug is considered a “mainstay” treatment for gram (-) bacilli?
aminoglycoside
Streptomyces derived aminoglycosides end in _________
-mycin
Micromonospora derived aminoglycosides end in _______
-micin
MOA of aminoglycosides
bind to 30S subunit
What category of drug are aminoglycosides?
protein synthesis inhibitor
Why do aminoglycosides have poor gut absorption?
they’re highly polar and polycationic
Why does neomycin need to be given orally?
its highly nephrotoxic
In what form are most aminoglycosides given?
parenterally
With what drug must you monitor the peaks and troughs?
aminoglycosides
What is the major AE of aminoglycoside?
ototoxicity
What category of drug are macrolides?
protein synthesis inhibitor
MOA of macrolides
bind to 50S subunit
Erythromycin is what kind of drug?
macrolide
Erythromycin has similar coverage as what other drug?
penicillin G
Clarithromycin is what kind of drug?
macrolide
Azithromycin is what kind of drug?
macrolide
Compared to erythromycin, clarithromycin has better coverage over what four bugs?
H. influenza
chlamydia
legionella
ureaplasma
