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Pharm test 2 > Antiretrovirals > Flashcards

Antiretrovirals Flashcards

1
Q

NRTIs

A

nucleoside OR nucleotide reverse transcriptase inhibitors

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2
Q

NNRTIs

A

non-nucleoside reverse transcriptase inhibitors

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3
Q

PIs

A

protease inhibitors

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4
Q

MOA of NRTIs

A

incorporates into growing HIV viral DNA strand by reverse transcriptase - terminating synthesis

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5
Q

What are the possible AE of NRTIs?

A

Lactic acidosis

Hepatomegaly w/steatosis

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6
Q

What class of drug is zidovudine?

A

NRTI

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7
Q

What class of drug is lamivudine?

A

NRTI

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8
Q

What class of drug is emtricitabine?

A

NRTI

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9
Q

What class of drug is didanosine?

A

NRTI

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10
Q

What class of drug is stavudine?

A

NRTI

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11
Q

What class of drug is abacavir?

A

NRTI

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12
Q

What class of drug is tenofovir?

A

NRTI

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13
Q

Lamivudine + zidovudine

A

combivir

NRTI

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14
Q

Abacavir + lamivudine + zidovudine

A

trizivir

NRTI

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15
Q

Tenofovir + emtricitabine

A

truvada

NRTI

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16
Q

Abacavir + lamivudine

A

epzicom

NRTI

17
Q

Tenofovir + emtricitabine + efavirenz

A

atripla

NRTI

18
Q

MOA of NNRTIs

A

directly bind to reverse transcriptase to inhibit transcription

19
Q

Which class of drug, NRTI or NNRTIs do NOT require phosphorylation to be active?

20
Q

What class of drug is delavirdine?

21
Q

What class of drug is nevirapine?

22
Q

What class of drug is Efavirenz?

23
Q

What is an AE of efanvirenz?

A

vivid dreams, drowsiness or insomnia

24
Q

MOA of protease inhibitors

A

bind to protease preventing the cleavage and inhibitor the assembly of new HIV viruses

25
Q

With what class of drug may you have hypercholesterimia or insulin resistance?

A

Protease inhibitors

26
Q

What can you treat the PI induced hyperchloresterimia with?

A

fibric acid derivatives

HMG-CoA reductase inhibitor (statins)

27
Q

In what type of pt are NRTIs contraindicated?

A

kidney disease

28
Q

What class of drug is enfuvirtide?

A

Fusion inhibitor

fuzeon

29
Q

What class of drug is marviroc?

A

chemokine receptor antagonists

30
Q

At what sites does marviroc bind?

A

CCR5

CXCR4

31
Q

At what site does marviroc block viral entry?

32
Q

What class of drug is raltegravir?

A

integrase inhibitors

33
Q

What drug is metabolized by UGT1A1 (glucuronidation)?

A

raltegravir

integrase inhibitor

34
Q

What class of drug has no induction or inhibition on CYPP450 enzymes or Pgp?

A

Integrase inhibitors

35
Q

What type of drug should you not combine with protease inhibitors?

36
Q

What PI is safe to combine with a PPI if administered w/RTV?

37
Q

What should you not combine with rifampin?

38
Q

What two drugs should you avoid using with ritonavir?

A

fluticasone

alfuzosin

Pharm test 2 (6 decks)

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