Protein Structure

Question 1

Peptide Bond Plane (what atoms are planar?)

Answer 1

Both alpha carbons, the carbonyl carbon and oxygen, the amide nitrogen and hydrogen

Question 2

Non-Energy Dependent Degradation

Answer 2

Done via acid hydrolases in lysosomes; typically extracellular proteins

Question 3

Energy Dependent Degradation

Answer 3

Ubiquitin-proteasome system; mainly endogenous proteins

Ubquitin conjugates lysine and initiates additional ubquitin recruitment –> delivery to proteasome filled w/ proteases for degradation

Ubiquitin receptors can remove ubiquitin so protein can be recycled instead of degraded.