Biochemistry Flashcards
Normal blood pH
7.35-7.45
Role of lungs in bicarbonate buffer system
Remove CO2; equation shifts to the left
Role of kidneys in bicarbonate buffer system
Reabsorption of HCO3- from urine, removal of H+ through urine
Metabolic acidosis
Occurs when HCO3- is low; caused by diarrhea and kidney failure
Respiratory acidosis
Occurs when CO2 is high; caused by COPD, asthma and pulmonary fibrosis
Metabolic alkalosis
Occurs when HCO3- is high; caused by vomiting and diuretic use
Respiratory alkalosis
Occurs when CO2 is low; caused by hyperventilation
5-Fluorouracil
Antitumor agent that inhibits human DNA synthesis bc of lack of 3’ OH
AZT
Antiretroviral (HIV) drug that inhibits reverse transcriptase bc of lack of 3’ OH
Acyclovir / Valacyclovir
Inhibits herpes DNA polymerase bc of lack of 3’ OH.
Remedesivir
Inhibits RNA synthesis by RNA polymerase in COVID-19
Non-polar, hydrophobic AAs
Val, Ile, Leu, Met, Ala, Gly, Pro
Aromatic AAs
Phe, Tyr, Trp
Polar, uncharged AAs
Ser, Thr, Cys, Asn, Gln
Polar, charged AAs
Basic (+) = Lys, His, Arg
Acidic (-) = Asp, Glu
A
Alanine (Ala)
R
Arginine (Arg)
D
Aspartic acid (Asp)
N
Asparagine (Asn)
C
Cysteine (Cys)
E
Glutamic acid (Glu)
Q
Glutamine (Gln)
G
Glycine (Gly)
H
Histidine (His)
I
Isoleucine (Ile)
L
Leucine (L)
K
Lysine (Lys)
M
Methionine (Met)
F
Phenylalanine (Phe)
P
Proline (Pro)
S
Serine (Ser)
T
Threonine (Thr)
W
Tryptophan (Trp)
Y
Tyrosine (Tyr)
V
Valine (Val)
