Protein Domains Flashcards

1
Q

What does the SH3 domain bind to?

A

proline-rich peptides

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2
Q

What does the SH2 domain bind to?

A

phosphotyrosine-containing target peptides

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3
Q

What does the PH domain bind to?

A

phosphorylated inositol phospholipid

lipids

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4
Q

What does the PTB domain bind to?

A

phosphotyrosine-containing target peptides

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5
Q

Explain the role of SH2 domain in protein function.

A

They bind to phosphorylated tyrosine residues

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6
Q

What is the PX domain’s binding function?

A

PI binding

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7
Q

What is the PLD domain’s binding function?

A

catalytic activity

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8
Q

What is the PH domain’s binding function?

A

role in targeting enzyme to locations within the cell

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9
Q

What does the FYVE domain bind to?

A

PI(3)P

phosphatidylinositol 3-phosphate

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10
Q

What does the PH domain bind to?

A

specific phosphoinositides such as phosphatidylinositol- 4,5-bisphosphate (PI(4,5)P)
PI-3
4-P2
PI-3,4,5-P3.

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11
Q

What does the PB1 domain bind to?

A

Cdc24, p40Phox, PKCZ, etc..

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12
Q

What does the PDZ domain bind to?

A

lipids and C-terminal peptides

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