Protein Domains Flashcards
What does the SH3 domain bind to?
proline-rich peptides
What does the SH2 domain bind to?
phosphotyrosine-containing target peptides
What does the PH domain bind to?
phosphorylated inositol phospholipid
lipids
What does the PTB domain bind to?
phosphotyrosine-containing target peptides
Explain the role of SH2 domain in protein function.
They bind to phosphorylated tyrosine residues
What is the PX domain’s binding function?
PI binding
What is the PLD domain’s binding function?
catalytic activity
What is the PH domain’s binding function?
role in targeting enzyme to locations within the cell
What does the FYVE domain bind to?
PI(3)P
phosphatidylinositol 3-phosphate
What does the PH domain bind to?
specific phosphoinositides such as phosphatidylinositol- 4,5-bisphosphate (PI(4,5)P)
PI-3
4-P2
PI-3,4,5-P3.
What does the PB1 domain bind to?
Cdc24, p40Phox, PKCZ, etc..
What does the PDZ domain bind to?
lipids and C-terminal peptides