Protein control: lipid metabolism 3 integration of metabolism

Question 1

What processes in the liver are promoted by insulin (fed state)?

Answer 1

Increased phosphorylation of glucose -> G6P
Glycogen synthesis
Activity of PPP
glycolysis
FA synthesis
TAG synthesis

Question 2

What processes in adipose tissue are promoted by insulin (fed state)?

Answer 2

Increased glucose uptake
rate of glycolysis
activity of PPP
FA synthesis
Supply of chylomicrons
TAG synthesis

Question 3

What processes in the liver are promoted by glucagon (fasted state)?

Answer 3

Increased rate of glycogen degradation
gluconeogenesis
FA oxidation
Ketone body synthesis

Question 4

What processes in adipose tissue are promoted by glucagon (fasted state)?

Answer 4

Increased degradation of TAGs

increased release of FAs

Question 5

Defect in type 1 diabetes?

Answer 5

beta cells are destroyed, eliminating production of insulin

Question 6

Complications of untreated type 1 diabetes?

Answer 6

Hyperglycaemia - impaired glucose uptake from food, excess glucose production by liver

Ketoacidosis - Increased mobilisation of FAs from adipose, accelerated FA oxidation in liver

Hypertryglycerolaemia - elevated production of VLDL in liver, low activity of LPL at adipose + skeletal muscle