prosthetic joint infection Flashcards
what organisms is prosthetic shoulder arthroplasty infection
coagulase negative staphylococci
most common prosthetic hip and knee arthroplasty infection organism
gram positive cocci
risk factors for infection in prosthetic joints
rheumatoid arthritis diabetes mellitus malignancy chronic kidney disease obesity lymphedema immunosuppression Use ofcorticosteroids, tumor necrosis factor inhibitors, and other biologic disease-modifying antirheumatic drugs
mechanism of prosthetic joint infection
direct inoculation at time of surgery
manipulation of a joint
hematogenous spread
characteristics of haematological spread
abrupt onset systemically unwell S. aureus GNB DAIR
what bacteria for chronic infection
CoNS cutibacterium corynebacterium S aureus symptoms are subtle
what are planktonic bacteria
reproducing rapidly
very active
metabolism is activated
biofilm definition
A microbe- derived sessile community
Characterised by cells that are attached to a substratum, interface or each other
Are embedded in a matrix of extracelular polymeric substance and
Exhibit an altered phenotype with respect to growth, gene expression and protein production
how do you diagnose PJI
culture
blood culture
CRP
radiology
what bacteria for most prosthetic joint infections
coagulase negative staphylococci
treatment for staphylococcus epidermis
vancomycin initially
treatment for prosthetic joints
remove all prosthesis and cement DAIR 1 stage exchange 2 stage exchange ( re-implantation of the joint after aggressive antibiotic therapy) girdleston antimicrobial suppressive therapy therapy for 6 weeks in 2 stage 12 weeks in DAIR rifampin
