prostate histopath

Question 1

Answer 1

Normal prostate; smooth, walnut-sized, 20-25 mL

Question 2

Answer 2

Prostate normal histology:

Glands: basal cells (red arrow), luminal/secretory cells (yellow)

Stroma: smooth muscle (blue “x”)

Question 3

Answer 3

BPH: see hyperplasia of transition zone and periurethral zone; can lead to bladder outlet obstruction (BOO)

Question 4

Answer 4

BPH nodule: see increase in glands and stroma, but all normal appearing

Question 5

Answer 5

BPH: see hyperplasia of prostate tissue, but otherwise normal appearing

Question 6

Answer 6

High Grade Prostatic Intraepithelial Neoplasia (HGPIN): several architectural forms: flat (top), tufting (bottom L), regular (bottom R)

histology: luminal cell crowding, hyperchromasia, clumping, and prominent nucleoli

HGPIN on a bx means 20-25% risk of carcinoma on subsequent bx’s (should re-check in 6 month)

Question 7

Answer 7

high grade basal cells, seen in patchy distribution

Question 8

Answer 8

1 CA in men, #2 killer of men w/ CA

Prostate Adenocarcinoma (CaP)

Heterogenous and multifocal appearance

Question 9

Answer 9

Prostate adenocarcinoma: multifocal and heterogenous

Question 10

Answer 10

Prostate Adenocarcinoma: benign and tumor cells share same compartment

Question 11

Answer 11

Prostate Cancer:

haphazard architecture w/ small invasive glands

Loss of basal cells

hyperchromatic, enlarged nuclei

prominent nucleoli

“blue intraluminal mucin”

intraluminal crystalloids

perineural invasion