penile histopath

Question 1

Answer 1

Left: hypospadias—urethral opening on ventral surface of penis; 1/300 live births

Right: Epispadias: abnormal urethral opening on dorsal aspect of shaft; even rarer

Question 2

Answer 2

Peyronie’s dz: localized fibromatosis of penile shaft resulting in painful erections

Question 3

Answer 3

Penile Infections:

Left: HSV

Right: Syphillis chancre

Question 4

Answer 4

Condyloma accuminata (genital warts); due to HPV 6 & 11

Question 5

Answer 5

Penile carcinoma = SCC; related to HPV infection (serotypes 16 and 18); circumcision is protective; uncommom in USA, more common in Africa & Asia

Tx: surgical removal with adjuvant RT to groin lymph nodes for more advanced lesions

Question 6

Answer 6

SCC of the penis; well differentiated SCC’s make lots of keratin (PINK); poorly differentiated SCC’s do not; keratin pearls