endometrium/uterine pathology

Question 1

endometrium

Answer 1

Secretory endometrium: normal part of endometrium cycle; see pink, bubbly glandular cells; may mimic a polyp on US

Question 2

endometrial mass

Answer 2

Endometrial polyp: benign growths that enlarge with estrogen stimulation; histologically are mixed dilated and small, with fibrous stroma, thick-walled BV’s, and simply hyperplasia

Question 3

Section of endometrium

Answer 3

Chronic endometritis; see characteristic plasma cells on histopath; associated with retained placenta, IUD, or gonorrhea infection

Question 4

Endocervical mass

Answer 4

Benign polyp: hypocellular stroma

Question 5

Uterine mass

Answer 5

Leiomyoma (fibroid):

A) normal uterine tissue

B) fibroid: well circumbscribed, well defined border, tissue is disorganized, but no angiolymph invasion—>BENIGN

Question 6

Answer 6

Menstrual Phase of uterine cycle, D1-D5; E & P fall –> spiral arterioles constrict –> fxn’l layer of endometrium becomes ischemic –> hemorrhage and necrosis forming menses

Question 7

Answer 7

Proliferative Phase of Uterine Cycle; D6-D14; E levels increase stimulating growth/activity of myometrium; see regeneration glands, stroma, and spiral arterioles in basal endometrium

cells possess ER, and estradiol stimulates synthesis of PR

Question 8

Answer 8

Secretory Phase of Uterine Cycle; D15-D28; very vascular and lots of nutrient rich fluid secreted;

A) endometrial glands: coiled with squiggly sides; lined by pale epithelial cells secreting fluid rich in glycoproteins, sugars, and aa’s.

B) myometrium: activity suppressed by high P

C) spiral arterioles: increase in #

D) endometrial stroma: thick and edematous