Prostaglandins 💊💊 Flashcards
What is prostaglandins
Are derivatives of prostanoic acid. Acting as a local homone
States the preparations of prostaglandins
1.Tablets
2. vagina suppository/ vagina pessary 3.parentral
State the classifications of PGEs
1.PGE¹ –misoprostol
2.PGE² –dinoprostone
3.PGE³–carboprost
What is Misoprostol
It is a methy Ester of PGE1
State the mode of action of misoprostol
It act on the myometrum causing cervical ripening
State the indications for misoprostol
1.Induction of abortion
2.induction of labor
3.acceleration of labor
4.management of atonic postpartum hemorrhage
State the contraindications of misoprostol
1.Hypersensitivity to drugs
2.uterus scar
3.pelvic inflammatory disease
4.hepatic and renal disorder
State the adverse effects of misoprostol
1.Tacysytole(hyper stimulation)
2. Meconium passage
What is dinoprostone?
It is a PGE2 prostaglandin
State the mode of dinoprostone
Change in myometrial cell membrane
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permeability or alteration of the membrane band calcium
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then it produces strong uterine contractions of the smooth muscles of uterus
State the indication of Dinoprostone
1.Induction of abortion
2.Induction of labor
3.acceleration of labor management of 4.atonic postpartum hemorrhage
5.Termination of molar pregnancy
6.Management of ectopic tubal pregnancy
State the contraindications of dinopro stone
1.Hypersensitivity to drugs
2.uterine scar
State the side effect of Dinoprostone
1.Vomiting and diarrhea
2.nausea
3.dysmenorrhea-like pain
4.breast tenderness
5.UTI uterine rupture
State the advantage of prostaglandins over oxytocin
1.Has powerful oxytoxic effects
2.more effective than oxytocin
Disadvantages of prostaglandins
1.It is costly
2.Tachysystole
3.Nausea
4.Vomiting
