Antihypertensive π₯π₯ Flashcards
What is antihypertensives
Are drugs given when BP is 160/110mm of Hg to protect mother from cerebral hemorrhage, cardiac failure, placenta abruption
What is the first line therapy of antihypertensive
Methyldopa
Nifedipine(2nd)
What is the mode of action of antihypertensives
Change in myometrial cell membranepermeability
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or alteration of the membrane band calcium
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then they synthesize myometrium to produce uterine contractions
State the indication of anti hypertensive
1.Induction of abortion
2.Induction of labor
3.acceleration of labor management of 4.atonic postpartum hemorrhage
5.Termination of molar pregnancy
6.Management of ectopic tubal pregnancy
State the contraindication of antihypertensive
1.Hypersensitivity to drugs
2.uterus scar
3.pelvic inflammatory disease
4.hepatic and renal disorder
State the side effects of antihypertensive
- Reproductive system: uterine rupture
- Vascular disorder: hypertension
- Pregnancy puerperium and perinatal conditions: amniotic fluid embolism
State eight antihypertensive drugs
- Methyldopa
2.Labetalol
3.Nifedipine
4.prazocin
5.propranol
6.sodium Nitroprusside
7.diuretics
State the mode of methyldopa
Stimulate Central π-adrenergic receptors
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Resulting in decrease of arterial pressure
State the dose of methyldopa
Orally- 250mg - 500mg
IV -250mg - 500mg
State the indication for antihypertensive
1.Hypertension
2. Gestational hypertension (PIH)
3. Preeclampsia
State the side effects of antihypertensive drugs on the mother
Postural hypertension
hemolytic anemia
Sodium retention
State the side effects of antihypertensive drugs on the fetus
Intestinal illeus
State the contraindication for antihypertensive drugs
Hepatic disorders
Psychic patients
CCF
State the mode of action of labetalol
Decrease in systematic arterial blood pressure and systemic vascular resistance
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because of its combine π-Ξ²-adrenergic blocking activity
State the indication for labetalol
Hypertension
Severe hypertension
Hypertensive emergencies
Side effects of labetalol on the mother and fetal
Postural hypotension
sodium retention
intestinal ilieus
State the contraindication for labetalol
Hepatic disorders
State the dosage for labetalol
Orally:100mg t.i.d.
IV: 1-2mg/min until desired results
What is propanol (1NN)
Is a sympatholytic non- selective beta blocker
State the mode of action of propanol
A non selective better blocker that reduces cardiac oxygen demand
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by blocking catecholamine-induced increases in heart rate blood pressure and force of myocardial contraction
State the dosage of propranol
Orally 80 to 240 mg
What is the indication for propranol
Hypertension
State the side effects of propranol on the maternal
Severe hypotension
Sodium retention
Bradycardia
Bronchospasm
Cardiac failure
Hypoglycemia
State the side effects of propranol on the fetal
Bradycardia
Impaired fetal response to hypoxia
IUGR(intrauterine growth restriction) when began a first and second trimester
Neonatal hypoglycemia
bronchial asthma
Renal insufficiency
diabetes
Contraindications for propranol
Bronchial asthma
Cardiogenic shock
What is prazosin
It is a sympatholytic drug used to treat high blood pressure
State the dosage of prazosin
Orally: 1 mg b.i.d
What is the indication for prazosin
Hypertension
State the side effects prazosin
Hypotension
Nasal congestion
Fluid retention
State the contraindication of prazosin
Hypotension
Syncope
What is nifedipine
It is a diehydro pyridine calcium Channel blocker
State the mode of action of nifedipine
Calcium Channel blockers
(Nifedipine)
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Block the entry of calcium ions from ECF to ICF
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Reduces the contractilty of muscles
State the dose of nifedipine
Orally 5 to 10 mg
State the indication for nifedipine
Pre term labor
Hypertension
Chronic or stable angina
State the side effects of nifedipine
Flushing
Hypotension
Headache
Tachycardia
Inhibition of labor
Bradycardia
Ankle edema
Constipation
Placenta ischemia
heart block
State the contraindications of nifedipine
It could be hazardous due to his synergic effects
Bradycardia
Cardiogenic shock
Systolic pressure<90mmhg
Sick sinus syndrome
Left ventricle dysfunction
What is sodium Nitroprusside
It is a potent vasodilator
What are the preparations or types of sodium Nitroprusside
Nipride
Nitopress
State the mechanism of action of sodium Nitroprusside
Directly relaxes arteriolar venous smooth muscles
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Resulting in reduction of cardiac preload and afterload
State the indication for sodium Nitroprusside
Hypertensive crisis
To reduce bleeding by creating hypotension during pregnancy
State the contraindications of sodium Nitroprusside on maternal
Nausea
Vomiting
Severe hypotension
restlessness
Decrease reflexes
Loss of consciousness
