Prostaglandins

Question 1

PGs role in reproduction

Answer 1

Luteolysis
Contraction of smooth muscle (PGF2)

Question 2

PGs role in cardiovascular system

Answer 2

Platelets (TXA2) → vasoconstriction → aggregation
Endothelial cells (PGI2) →vasodilation → anti-aggregation
Patency of ductus arteriosus in utero (PGI2)
Endotoxin by gram- bacteria (TXA2, PGI2)

Question 3

What triggers PGE2 and PGI2 release?

Answer 3

Low blood pressure (intrarenal baroreceptors)
↓ Na and Cl retention
stimulates renin release

Question 4

PGs response to reduced circulating blood volume

Answer 4

PGI2 and PGE2 ↑ renal blood flow, GFR and prevent ischemia of renal tissue

Question 5

PGs in GIT protection

Answer 5

PGI2 and PGE2 ↓ acid secretion, stimulate mucus and bicarbonate secretion, alter mucosal blood flow

Question 6

Misoprostol

Answer 6

PGE1 analogue (gastric protection)
Use: NSAID induced ulcers and healing peptic ulcer

Question 7

What else can misoprostol be used for?

Answer 7

Canine atopic dermatitis
Adjunct in inducing abortions in bitches

Question 8

Dinoprost (lutalyse)

Answer 8

PGF2a
Luteolytic agent, termination of pregnancy, induction of parturition and abortion, estrus synchronization
Like cloprostenol

Question 9

What does dinoprost treat?

Answer 9

Subestrus, metritis and open pyometra, mating-induced persistent endometritis