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IV Anesthetics > Propofol > Flashcards

Propofol Flashcards

0
Q

Protein binding

A

95-99%

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1
Q

Mechanism of action

A

Interaction with GABA
Delays association of GABA from receptors
Increasing GABA activated opening of Cl channel
Acts as a Na channel blocker
Hyper polarization of cell membranes

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2
Q

Elimination half life

A

30-60 mins

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3
Q

Metabolized

A

Glucoronidation in the liver
Clearance exceeds hepatic blood flow
30% may occur in lungs

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4
Q

Excretion

A

Renal

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5
Q

Therapeutic window

A

Plasma concentration 1.5-2 mcg/ml

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6
Q

Cardiovascular effects

A

Decrease systolic BP, SVR, HR

arterial and venous vasodilation decrease preload and afterload

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7
Q

Pulmonary effects

A

RR depressed dose dependent
Apnea after bolus
Reduces airway reflexes

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8
Q

CNS effects

A

decreased cerebral blood flow, ICP, CMRO2, IOP

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9
Q

Caution with decrease systolic and cerebral blood flow

A

Decreased CPP

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10
Q

Supplied at

A

10 mg/ml

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11
Q

Older adult doses

A

Reduce dose

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12
Q

Children dose induction

A

2.5-3.5 mg/kg

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13
Q

Onset of unconsciousness

A

30-60/ seconds

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14
Q

Sedation dose

A

25-100 mcg/kg/min

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15
Q

Anesthesia dose (TIVA)

A

100-300 mcg/kg/min

16
Q

Is propofol an analgesic?

A

NO

17
Q

Bacteria

A

Bacteria forms in the bottle and in the syringe and can keep up to 6 hours

18
Q

Propofol infusion syndrome

A 
Acute refractory bradycardia (kids)
-RBBB early sign 
-asystole 
Metabolic acidosis
Rhabdomyolisis
Hyperlipidemia
Enlarged fatty liver
>4mg/kg longer than 48 hrs
19
Q

Awaken why

A

Redistribution

20
Q

Greater CV depression than

A

NaP

21
Q

Similar respiratory effects as NaP except

A

Good bronchodilator

22
Q

Does NOT cause

A

Hyper analgesia

23
Q

What happens with N/V

A

Reduces PONV & PDNV

24
Q

Produces

A

Hypnosis

25
Q

IV administered

A

Burns on injection in small vein

26
Q

Allergy

A

To eggs

IV Anesthetics (15 decks)

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