Ketamine Flashcards
0
Q
Lipid solubility
A
Extremely
1
Q
Mechanism of action
A
NMDA, opioid, monoaminergic, muscarinic receptors, voltages gated Ca channels
2
Q
Metabolized
A
Liver to nor ketamine(1/3-1/5 potency ketamine)
3
Q
Nor ketamine hydrolyzed
A
H2O soluble and excreted
4
Q
Excretion
A
> 90% renal
5
Q
Cardiovascular effects
A
increased SBP, HR, SVR
6
Q
Pulmonary effects
A
Respiratory depression
Increased with opioids
7
Q
CNS effects
A
increased CBF, ICP, CMRO2
8
Q
Supplied
A
10mg/ml
50 mg/ml
9
Q
Induction of anesthesia
A
1-3 mg/kg IV
4-8 mg/ml IM
10
Q
Adjunctive analgesic
A
0.2-0.5 mg/kg
11
Q
Caution of
A
Emergence delirium
Visual, auditory, proprioceptive, confusion
12
Q
Prevent of help with emergence delirium
A
Premeditated with midazolam
13
Q
Derivative
A
Phencyclidine
14
Q
Produces
A
Dissociative anesthesia and analgesia
