Etomidate Flashcards
0
Q
Protein bound
A
75%
1
Q
Mechanism of action
A
Rapid onset of sleep 30-60 seconds Rapid awakening Enhance GABA GABA A receptors with B3 subunits rapid awakening
2
Q
Hydrolyzed
A
To inactive metabolites via ester hydrolysis
3
Q
Elimination half life
A
75 mins
4
Q
Clearance
A
5x Pentothal
5
Q
Excretion
A
85% renal
15% biliary
6
Q
CV effects
A
Doesn’t effect SNP, HR, SVR
Preserves function
7
Q
Pulmonary effects
A
Minimal respiratory depression
Increased with opioids
8
Q
CNS effects
A
decrease CBF, ICP, CMRO2
9
Q
Supplied
A
2mg/ml
10
Q
When administered IV
A
Burns on injection
11
Q
Caution with
A
Myoclunus
Adrenal suppression
12
Q
Adrenal suppression
A
Inhibits 11B-hydroxylase and to a less
re extent 17a-hydroxylase
Decrease cortisol & aldosterone
13
Q
Nausea
A
Increased compared to NaP or propofol
14
Q
Analgesia effects
A
None
