Barbiturates Flashcards
0
Q
Protein bound
A
NaP 83% bound
1
Q
Mechanism of action
A
Interact with GABA-A subunit receptor Directly activate Cl channel Increase duration of opening Increase efficacy of GABA Hyperpolarize post synaptic cell membranes Block AMPA
2
Q
Lipid soluble
A
Highly- enters CNS Rapidly 30 secs
3
Q
Awakening after single dose
A
Prompt
4
Q
Metabolism
A
Hepatic (inactive)
5
Q
Eliminated
A
Kidneys
6
Q
Cardiovascular effects
A
decrease SBP, SVR
Increase HR
7
Q
Pulmonary effects
A
Respiratory depression
Apnea
Return with slow respers
Decreases tidal volume
8
Q
CNS effects
A
Decrease CBF, ICP, CMRO2
9
Q
Renal effects
A
Modest decrease in blood flow and GFR
10
Q
pH
A
Metabolic acidosis increase effect of barbs
Metabolic alkalosis decreases effect of barbs
Respiratory acidosis much less effect
11
Q
Thiopental supplied
A
2.5% solution
12
Q
Methohexital supplied
A
1% solution
13
Q
Induction of anesthesia
A
3-5 mg/kg NaP
1-1.5 mg/kg methohexital
Rectal methohexital 20-30 mg/kg sedative
14
Q
Caution if infiltrated
A
Tissue sloughing
