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ANALGESIA, ANESTHESIA, AMNESIA, PARALYTICS AND SEDATIVES > PROPOFOL > Flashcards

PROPOFOL Flashcards

1
Q

Drug Class

A

Alkylphenol intravenous anesthetic agent

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2
Q

Indications

A

Induction of General Anesthesia
Maintenance of Anesthesia
Procedural Sedation

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3
Q

Mechanism of Action

A

Not well described

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4
Q

Adult Induction Dose

A

2-2.5 mg / kg IV

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5
Q

Administration Considerations

A

Solution is irritating - use lidocaine BEFORE

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6
Q

Onset

A

Within one arm-brain circulation time (approx. 20 seconds)

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7
Q

Duration

A

Approx 5-8 min after single induction dose.

Offset of action is more prolonged when administered as continuous infusion.

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8
Q

Elimination half time

A

0.5 - 1.5 hrs

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9
Q

Elimination

A

Rapid redistribution into lean body compartments

Very lipophilic

Metabolized by liver and extra hepatic sites

Excreted by kidneys

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10
Q

CNS Effect

A

CNS Depressant: sedation - anesthesia

NO ANALGESIC properties

Variable amnesia

Potentiates depressant effect of opioids, sedative, volatile anesthetics.

Decreased cerebral metabolic rate and intracranial pressure.

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11
Q

CVS Effects

A

Direct myocardial depressant

Vasodilation leading to hypotension

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12
Q

Respiratory Effects

A

Depression of respiratory centers leading to brief apnea

Blunts airway response to manipulation (i.e. no bronchospasm)

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13
Q

GI Effects

A

Anti-emetic

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14
Q

Contraindications

A

Egg or say allergy

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15
Q

Precautions

A

Poor left ventricular function

Critcal coronary artery insufficiency

Serious illness

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16
Q

Storage Considerations

A

The emulsion supports bacterial growth - use asceptic techniques and DO NOT leave open / drawn for > 4 - 6 hrs

17
Q

Pediatric Induction Dose

A

3-4 mg / kg IV

18
Q

Maintenance Infusion Dose

A

100-200 ug / kg / min
0-4 mg/kg/h

19
Q

Procedural Sedation Dose Outside of Operating Room

A

0.5 - 1 mg / kg followed by 0.25 - 0.5 mg / kg q 1 - 3 min PRN

20
Q

Sedation Infusion Dose

A

40-100 ug / kg /min
0-4 mg/kg/hr
10mg/ml

21
Q

RSI Dose

A

1.5 - 2 mg / kg IV

ANALGESIA, ANESTHESIA, AMNESIA, PARALYTICS AND SEDATIVES (15 decks)

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