NEOSTIGMINE Flashcards
1
Q
Class
A
Anticholinesterase
2
Q
Mechanism of Action
A
Inhibits the breakdown of acetylcholine in the synaptic cleft by inhibiting the cholinesterase enzyme
3
Q
Dose
A
0.05 mg / kg
Must not exceed 5 mg
Must be administered with glycopyrolate 0.01 mg / kg or Atropine 0.015 mg / kg
4
Q
Onset
A
5 min
5
Q
Elimination
A
Hepatic
Plasma esterases
6
Q
CNS Effects
A
Seizures
7
Q
CVS Effects
A
Bradycardia, AV Block, Nodal Rhythm, Hypotension
8
Q
Respiratory Effects
A
Increased oral and bronchial secretions, bronchospasm
9
Q
GI / GU
A
Increased peristalsis: diarrhea, urinary frequency
10
Q
Misc. effects
A
Overdose may cause a cholinergic crisis
