Properties and Functions of Endothelium

Question 1

Endothlial Cells are anchored down via

Answer 1

Basal Lamina Matrix

Composed of laminin and collagen IV

Question 2

Endothelial Tight junctions are composed of

Answer 2

ZO-1
Occludin
Claudin

Question 3

Adheren Junctions utilize

Answer 3

Calcium-dependent cell-cell adhesion

alpha and beta catenin

Question 4

Function of Large Artery Endothelial Cells

Answer 4

Elastic

Question 5

Function of medium artery endothelial cells

Answer 5

Conducting arteries

Question 6

Function of Small arteries endothelial cells

Answer 6

vasoresponsive

Question 7

Function of Capillary endothelial cells

Answer 7

barrier function

Question 8

Function of post-capillary venules

Answer 8

cell trafficking

Question 9

Characteristics of Blood Brain Barrier

Answer 9

Glucose and AA transporters
Membrane pumps
Astrocyte Projection called podocytes support EC structure and barrier function

Question 10

Regulators of Adherens Junctions and Permeability in EC

Answer 10

Thrombin
Histamine
Leukocytes
VEGF
Platelet Products

Question 11

Role of expression of GAGs

Answer 11

Made by the endothelial cells
makes a non-adherent surface
i.e. makes vessels smooth

Question 12

Nitric Oxide

Answer 12

Produced by Endothelial Cells
Ca activates endothelial nitric oxide synthetase
via Ach activation of Gq
cytokines activitate iNOS i.e. inflammation NO synthetase