Angiogenesis Flashcards
1
Q
How does hypoxia induce VEGF-A
A
HIF-Beta activates HIF
HIF transcribes VEGF-A
VEGF-A promotes angiogenesis
2
Q
Difference between HIF- Alpha and HIF-Beta
A
HIF alpha is constitutively formed and degraded
PHDs degrade HIF-alpha
3
Q
Difference between tip cells and stalk cells and filopodia
A
Tip cells never proliferate, but guide migration
Stalk cells are highly proliferative
Filopodia are VEGF-A sensing tips (express VEGFR-2)
4
Q
Which type of cell secretes VEGF-A and guides vascular patterning
A
Schwann cells of PNS secretes VEGF-A and guids the development of blood vessels
5
Q
What signaling protein released from the bone marrow recruits cells for angiongensis?
A
SDF-1 is abundant in hypoxic environments and recruits BM derived cells to promote angiogenesis.
