Pro- and anti-inflammatory mediators Flashcards

1
Q

what is key factor for development of sepsis?

A

inflammation

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2
Q

How is infection/injury controlled?

A

proinflammatory + anti-inflammatory mediators

= balance of these localize infection/ injury host tissues

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3
Q

How are proinflammatory mediators facilitated?

A
  1. clearance injuring stimulus
  2. promotes resolution of injury
  3. process damaged tissues
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4
Q

What do anti-inflamm mediators control?

A

intensity + duration inflamm response

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5
Q

what happens when equilibrium of inflammtory process is losts?

A

systemic responses occur

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6
Q

How is inflamm process in sepsis linked to coagulation system ?

A
  1. Pro-inflamm mediators - procoagulant + antifibrinolytic effects
  2. Anti-inflamm mediators - fibrinolytic effects
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7
Q

What protein is a key factor in sepsis inflammation and what does it enhance ?

A
  • Activated protein C
  • enhances fibrinolysis
  • inhibits inflamm
  • decrease levels = many septic patients
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