Inotropic therapy Flashcards

1
Q

When is inotropic therapy initiated?

A
  • fluid resuscitation is ineffective
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2
Q

How effective is inotropic agents in treating sepsis?

A

treat life threatening hypotension + improve cardiac output

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3
Q

why are adrenergic agents titrated slowly ?

A

due to complications like tachycardia + myocardial ischaemia

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4
Q

MOA and use adrenaline (epinephrine)

A
  • 1st line
  • non-selective alpha , B adrenergic agonist
  • increase CO + peripheral vasoconstriction
  • increase lactate level = impair BF to splanchnic system (internal organs )
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5
Q

MOA Dobutamine

A
  • B-adrenergic agonist = increase CO + O2 delivery

- ONLY used in septic patients - adequate filling pressure + BP + low CO

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6
Q

Dose of dobutamine

A

2-20mcg/kg/min - adults
5-15 mcg/kg/min - children
= increase CO , but HR increases significantly

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7
Q

MOA Dopamine

A
  • alpha, B adrenergic agonist with dopaminergic activity
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8
Q

Low dose of dopamine 1-5mcg/kg/min

A
  • maintain renal perfusion

= not used for renal protection as part of sepsis

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9
Q

High dose dopamine > 5mcg/kg/min

A
  • exhibit alpha + B-adrenergic act
  • support BP
  • improve cardiac func
    = increase SV + HR
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10
Q

causes of dopamine

A
  • tachycardia
  • potential arrhythmia
  • not used routinely for management septic shock
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