PRL + GH axis

Question 1

what cells produces PRL, where are they located

Answer 1

lactotrophic cells in the anterior pituitary

Question 2

what causes the anterior pituitary to produce PRL

Answer 2

anterior pituitary constantly produces PRL

Question 3

what controls the production of PRL

Answer 3

it is under constant tonic inhibition by dopamine

Question 4

what produces dopamine

Answer 4

hypothalamus

Question 5

what does dopamine act on, what is its affect

Answer 5

anterior pituitary

inhibits release of PRL

Question 6

what must tissues contain to be affected by PRL

Answer 6

PRL receptors

Question 7

what is GHRH, what does it do

Answer 7

growth hormone releasing hormone

acts on the anterior pituitary to cause the release of GH

Question 8

what produces GHRH

Answer 8

hypothalamus

Question 9

what is SS, what does it do

Answer 9

Somatostatin, acts on the anterior pituitary to reduce secretion of GH

Question 10

what produces SS

Answer 10

hypothalamus

Question 11

what releases growth hormone (GH)

Answer 11

anterior pituitary

Question 12

what does GH act on

Answer 12

target tissues
liver
adipose tissues

Question 13

what does GH induce when it acts on the liver

Answer 13

it causes the liver to secret IGF-1

Question 14

what does IGF-1 act on

Answer 14

same target tissues as GH

Question 15

what does GH induce when it acts on adipose tissue

Answer 15

production of free fatty acids

Question 16

what does leptin do, where do it act

Answer 16

acts on the anterior pituitary to increase secretion of GH

Question 17

what does the free fatty acids released from the liver do, where do they act

Answer 17

act on the anterior pituitary to decrease secretion of GH

Question 18

where is leptin released from

Answer 18

adipose tissues