Principles Flashcards

1
Q

Definition of drug

A

Any chemical that affects the physiologic processes of a living organism

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2
Q

What is Pharmacology

A

The study or science of drugs.”

(What do these chemicals-we-call-drugs do to us and what to we do to these chemicals-we-call-drugs?)

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3
Q

Three basic areas of pharmacology

A

Pharmaceutics (how dosage forms influence pharmacokinetics and pharmacodynamics)
Pharmacokinetics (what the body does to the drug)
Pharmacodynamics (what the drug does to the body)

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4
Q

Objective of pharm

A
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5
Q

Pharmacotherapeutics

A

The more clinically focused arm of pharmacology is called Pharmacotherapeutics, the study of drug actions when implementing drug therapy on specific clinical indications to prevent and treat disease.

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6
Q

Toxicology

A

specific to pharmacology, seeks to study the adverse effects of drugs on living organisms

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7
Q

Drug classifications based on

A

Action (what is being treated) OR on the body’s physiology

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8
Q

Prototype drug

A

A model for a drug class

Is a well understood
Has a known mechanism of action (how a drug produces its effect in the body) and known adverse effects
Is used to represent and compare other drugs in same pharmacologic class
Will be useful for you to concentrate on drug class prototypes when you study … (given for each drug family in your text)

The representative of this drug class

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9
Q

How many kinds of names does a Drug have

A

Chemical Name
Generic Name
Trade Name

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10
Q

Chemical name describes

A

The drugs chemical composition and moelcular structure

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11
Q

Generic name

A

Describes the chemical substance or pharmacological property of the drug.

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12
Q

Trade name

A

Propietrary name

The drug has a registered trademark use of the name resricted by the druges patent owner (usually manufacturer)

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13
Q

Clues to pharm class

A

Generic names of durvs in same pharm class often have same suffix

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14
Q

Drugs in a pharm class have similar attributes such as

A

Indications
Mechanisms of action
Contraindications and precautions
Interactions
Adverse Reactions and side effects

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15
Q

If you know about one drug in a class, you will have some knowledge of other drugs in the class T or F

A

True

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16
Q

Drugs in a pharm class may differ

A

Dosages and potency
- First, second, third + gens of drugs
Time action profile
Availability

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17
Q

Time action profile matters for

A

Knowing WHEN med should work
Helps us look out for side effects
Knowing when next dose COULD occur

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18
Q

ACE inhibitors abt drug in market

A

Includes at least 10 individual drugs

All end in “-pril”

Commonly prescribed drugs

Newer drugs have greater potency and require smaller amounts of drug or less dosing frequency

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19
Q

Drug classification schemas

A

Their action on a symptom/sign/condition
Ie., Antihypertensives, Antiemetics, Anticoagulants

Their action on a body system
Ie., drugs that affect the CNS, the Respiratory, the GI, the Endocrine systems

Their chemical nature
Ie., benzodiazepines, dopaminergics, glycosides, nitrates/nitrites

Their chemical action within the body
Ie., alpha blockers, beta blockers, opiods, vasodilators, bronchodilators

Their prescription category or OTC availability

Their clinical considerations (administration concerns)

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20
Q

Generic drugs are generally _____________ but may differ in their bioavailability ( the ability of the drug to reach its target tissue and produce an effect).

A

cheaper

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21
Q

The greatest barrier to drugs reaching their target cells

A

Diffusion (Passive and Active transport)

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22
Q

4 Parts of pharmacokinetics

A

Absorption
Distribution
Metabolsim
Excretion

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23
Q

Absorption of dru

A

(the movement of a substance from its site of administration, across body membranes to circulating fluids

Onset of action is faster

IV bipasses absorption and results in an immediate

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24
Q

Problem with IV meds

A

Non reversible

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25
Q

Fastest route of absorption

A

Inhaled

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26
Q

What factors increase or decrease the absorption of a drug

A

Food (slows absorption)
Digestive motility
Blood Flow

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27
Q

Lipid soluble medications work better

A

In body and absorption (Crossing cell layer)

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28
Q

Water soluble meds

A

Are excreted better

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29
Q

Drug Ionization

A

ASA is nonionized in the acidic environment of the stomach allowing it to be absorbed and distributed in the blood stream.
As it enters the alkaline environment of the stomach it becomes ionized and, in this form, it is not as likely to be absorbed and distributed.

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30
Q

Basic drugs are absorbed and distributed beteer in an ________ environments

A

Alkaline

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31
Q

A drug given via the oral route may be extensively metabolized by the ____ before reaching the _______ (high first-pass effect) and its target organ

A

Liver: systemic circulation

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32
Q

The same drug (PO) that is given parentally, (eg IV) - bypasses the liver preventingt the first pass effect from taking place and more drug gets into the general circulation and reaches its target organ

A

Same for mucosal, topical etc

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33
Q

Grapefruit juice can significantly _____ the absorption of some drugs

A

Increase

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34
Q

High fat meals can ___ the absorption of oral medications

A

Slow

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35
Q

Tyramine and MAOIs can cause a _______

A

HTN Crisis

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36
Q

Drug distribution

A

The transport of a drug in the body by the bloodstream to its site of action.
What factors would affect the distribution of a drug?

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37
Q

What factors affect distribution

A

Solubility
Blood Flow
Tissue storage

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38
Q

Areas of rapid distribution

A

Highly vascularized, or sites wiath a large blood volume

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39
Q

Not all drug molecules molecules in plasma will reach their target cells as they become bound to plasma ______especially albumin to form drug-protein complexes.

A

protien

Drugs bound to proteins will circulate in plasma until they are released or displaced. (Not intended effect)

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40
Q

A drug can only be freely distributed to extravascular tissue if it is not bound to protein (Why)

A

(if it is bound to protein it is too large to pass through capillary walls) thus it is not available for distribution.

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41
Q

Warfarin is ______ bound to plasma proteins

A

99%

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42
Q

ASA taken with Warfarin does what

A

if taken concurrently will displace Warfarin from the proteins.

At risk for hemorrhage

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43
Q

What do you do to avoid hemmorrhage

A

Provide antidote

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44
Q

Special Barriers preventing/affecting distribution

A

BBB
Fetal-Placental Barrier

45
Q

Drug Metabolism (Biotransformation)

A

The biologic transformation of a drug so that it may be excreted more readily .
This often changes the drug from lipid soluble (easily absorbed and distributed) to a more water soluble compound, (which will more readily be excreted

46
Q

Most drug metabolism occurs in the

A

Liver, where hepatic enzymes catalyze various biochemical reactions.

If liver DOESNT metabolize all drug, it cant all be excreted

47
Q

Metabolis. of DRUGS also occurs in the

A

kidneys, intestinal mucosa, lungs, plasma and placenta.

48
Q

Ability of liver to metabolize varies bc of

A

Genetics, liver disease, age

49
Q

How to know liver function

A

Liver Function Lab Test

Results increase with lower function

50
Q

Delayed drug metablism

A

accumulation of drug
Prolonged action of drug on target organ

51
Q

Increased drug metabolism caises

A

Diminished drug affect

52
Q

The rate at which drugs are excreted determine their ____. in the blood streamn

53
Q

Most elimination

A

Kidneys
Lumgs
Saliva/sweat
Breast milk

54
Q

CKD affect onf excretion

A

Prolonged drug action

55
Q

Small to moderate changes in renal status can cause rapid changes in _______; therefore, what should the RN monitor?

A

serum drug levels

Lab results

56
Q

Certain drugs may be excreted ________ if the pH of the filtrate changes

A

More quickly

57
Q

Non-ionized and lipid soluble drugs cross renal tubular membranes _____-

A

Easily, and then return to circulation

58
Q

Questions to ask when giving a drug

A

When, and how long will drug work
When do I first assess the pt for drug effect
How long do I need to moniter the pt

59
Q

Onset

A

When med starts to work
PO: Usually 20-30 mins

60
Q

Peak

A

When drug has maximum effect (highest conc of med in blood)

61
Q

Duration

A

How long is drug in therapeutic range (How long is it working for)

62
Q

Half Life

A

The time it takes for half of the original amount of a drug in the body to be conc in blood stream

Measure of rate at which drugs are removed from the body

63
Q

Meds with a short half life are given MORE or LESS frequently

64
Q

cSteady state serum level of drug

A

The amount of the drug eliminated is equal to the amount of the drug administered with each dose

Means that there are consistent levels of the drug in the body to achieve the desired therapeutic effect.

65
Q

How many half lives ususlly to accomplish steady state

A

4-5 half lives

66
Q

A drug with a long half life may take a _________ to achieve this state—sometimes a ‘______ ______’ is given.

A

Longer time; Loading dose

67
Q

Loading dose

A

High dose given right away. Then, subsequently, a lower dose is given to keep it at a steady state

68
Q

Efficacy

A

How efficient a drug is at creating a theraeptic effect

69
Q

How to monitor for adverse affects

A

VS
Focus on relevant systems effected

69
Q

Digoxin has a narrow thereapeutic index. What does that mean?

A

Monitor closely, assess for adverse effects

70
Q

One of the most fundamental concepts in pharmacy

A

A higher dose would have a greater effect

71
Q

If a dose is doubled, the response would have ______ the effect

72
Q

Potency

A

The relative amount of drug needed to produce a response

73
Q

A more potent drug will produce a therapeutic effect at a

A

Lower dose

74
Q

Efficacy is the ______ amount of response that can be produced from a drug

75
Q

Receptor interaction

A

S molecule to which a medication binds to initiate its effect

76
Q

Receptor interaction can be

A

Selective (binds with only one type of receptor)
Non selective (Binds with several types of receptors

78
Q

Non-selective or selcetive have more adverse effects

A

Non seelective, bc they bind with receptors they shouldnt

79
Q

Agonist

A

A drug can produce a response that mimics the effect of the endogenous regulatory molecule

80
Q

Partial Agonist

A

a medication that produces a weaker or less effective response than an agonist

81
Q

Antagonists

A

Block a receptor

82
Q

3 types of antagonists

A

Competitive (Protamine sulfate, antidote to heparin - in it’s presence the body loses the anticoagulant properties of heparin)

Noncompetitive: Attach to molecule and block it

Functional: Don’t bind to receptors - Slow absorption, metabolism, making drug less effective

83
Q

Do antagonists elicit a ersponse?

84
Q

Nonspecific Interactions

A

Often oncological drugs (chemotherapy) and some antibiotics work by incorporating the drug into a natural metabolic pathway, causing a defective end product, such as an improperly formed cell wall or lack of energy product, resulting in cellular death

85
Q

Once drug is at the site of action, it can

A

modify the tate (increase or decrease) at which the cell or tissue’s function

86
Q

A drug cannot make a cell or tissue perform a function it was not designed to perform

T or F

87
Q

What is your role in Preventing and Managing Drug Effects ?

A

Assess
Check MAR
Call Physician
Administer (3 Checks, ten rights)
Monitor for side effects and success

88
Q

The nurses role in medication administration

A

Obtain a medical HX
Thoroughly assess the client and all diagnostic data.
Prevent medication Errors
Monitor carefully
Know the drugs.
Be prepared for the unusual
Question unusual orders
Teach clients about adverse effects

89
Q

Our response to “I don’t take this med”

A

Always check

90
Q

How to question unusual orders

A

Check the MAR
Check the MD orders

91
Q

Tolerance

A

When you need more of the drug to produce the same desired effect (you are less sensitive)

92
Q

What aspect of pharmacotherapy must be monitored

A

Therapeutic index
Drug concentration
Patient’s condition
Tolerance and dependence
Interactions
Side effects/adverse drug effects (potential lethal and most common)

93
Q

Pharmacologic reactionsPharmacologic reactions (It works too good!

A

Pharmacologic reactions (It works too good!

94
Q

Idiosyncratic reactions

A

(Particular to the patient, but not a true allergy or a pharmacologic rxn; eg., pt develops migraine with Percocet)

95
Q

Allergic reactions

A

allergies—patient’s immune system decides to treat a drug as a dangerous character … and overreacts!)

96
Q

Why would a carcinogenic drug be used?

A

Benefits outweigh the risks

97
Q

Teratogens

A

Drugs that cause birth defect

98
Q

Dose depednedt effect

A

The adverse effect’s intensity and occurrence are frequently related to the size of the dose

99
Q

Expected adverse effects

A

well-known reactions that result in little or no change in patient management; i.e. side effects

100
Q

What type of data is gathered in the assessment

A

Baseline data
Subjective data
Objective data
Adverse effects
Rights related to administration of medication

101
Q

What is the health history composed of

A

Chief complain
Allergies
Past medical hx
Family Hx

102
Q

What is drug history composed of

A

Drug hx
Health management
Reproductive hx
Personal and social hx

103
Q

Plasma Proteins do what to drug distribution

A

High protein bound drug decreases amount of availble free drug

Distribution is decreased

High protein binding = high drug serum concentration

SOMETIMES the drug that is protein bound can be released into the blood stream extremely slowly

104
Q

Low protein binding of drug

A

Increased distribution, high conc in interstial fluid

105
Q

Major processes by which drugs are excreted

A

Kidneys (Most common)
(12 – bile (liver)
(13 – Exhalation (Lungs)
(14 – Feces (GI)

106
Q

. Explain how enterohepatic recirculation might affect drug activity.

A

Increasing drug concentration and half life through recycling out of bile excretions that are remetabolized by the liver

107
Q

Explain the applications of a drug’s plasma half-life (t1/2) to pharmacotherapy.

A

To do with the length of time the drug is present in circulation, matters for deciding when to give a subsequent dose

108
Q

Subagaonist

A

Drug causing a submaximal afffect than would normally be seen