Extra

Question 1

Phosphodiesterase III Inhibitors

Answer 1

Block the enzyme phosphodiesterase in cardiac and smooth which increases the amount of calcium available for myocardial contraction.

This inhibition results in two main actions; 1. a positive inotropic action which is?

Vasodilation, reduces afterload allowing cardiac output to increase

Increased force of myocardial contraction increasing cardiac output.

Tx of HF

AE: Vdysrthmias