Primary Immunodeficiency Flashcards
What is immunodeficiency?
A defect in one or more components of the immune system
What is a primary immunodeficiency?
One that is congenital (caused by mutations) that leads you susceptibility to infection, certain types of infection or autoimmunity
Where may the abnormality lie in primary immunodeficiency?
Components of the innate immune system
Stages of lymphocyte development
Responses of mature lymphocytes to antigenic stimulation
What does Repeated infection with encapsulated bacteria a sign of?
Immunodeficiency in which antibody production is defective
What does IgG or IgA deficiency result in ?
Pneumococcal or haemophilus infection
What does phagocyte deficiency result in?
Recurrent staph, gram -ve or fungal infections
What does a complement defect leave you prone to?
Meningitis caused by Nisseria meningitidis
What do defects in T Cells or macrophages exposes you to?
Intracellular organisms such as protozoa, viruses and intracellular bacteria
What is reactivation of HSV linked to ?
T-Cell immunodeficiency
What are the causes of primary immunodeficiency?
Mutations, polymorphisms or polygenic disorders
