Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology and Haematology > Lymphoid Disorders > Flashcards

Lymphoid Disorders Flashcards

1
Q

What is leukamia?

A

A cancer of the blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is lymphoma?

A

Cancer of lymphoid origin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How is leukaemia or lymphoma diagnosed?

A

Via bone marrow or lymph node biopsy Each type is defined by malignant cell characteristics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Give examples of high grade Non-Hodgkin Lymphoma

A

Diffuse large B-Cell lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Give examples of low grade Non-Hodgkin Lymphoma

A

Follicular lymphoma Marginal zone lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is acute lymphoblastic leukaemia ?

A

Cancer of lymphoid progenitor cell where the cells don’t differentiate but divide rapidly and accumulate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What will the investigations show in ALL?

A

Hb = 38g/l WCC = 370 x 10^9/L Platelets = 68x10^9/L Bone marrow will be ~ 90% B-lymphoblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the characteristics of ALL cells?

A

Large cells which express CD19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the consequences cytokine release syndrome?

A

Fever, hypotension, dyspnoea, dyspnoea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the consequences of T-Cell immunotherapy mediated neurotoxicity?

A

Confusion with normal conscious level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the typical presentation?

A

Bone marrow failure +/- raised white cell count Bone pain, infection, sweats

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the requirement for a CLL diagnosis?

A

A lymphocyte count of >5 where the abnormal cells are mature and slow growing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the associated findings of CLL?

A

Immune paresis Haemolytic anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the indications for treatment in CLL?

A

Progressive bone marrow failure Massive lymphadenopathy Progressive splenomegaly Lymphocyte doubling time <6 months or >50% increase over 2 months Systemic symptoms Autoimmune cytopenias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How does lymphoma present?

A

lymphadenopathy/ hepatosplenomegaly Extranodal disease “B symptoms” - fever, night sweats, weight loss bone marrow involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What classifies a non hodgkin lymphoma to appear as low grade?

A

Indolent, often asymptomatic responds to chemotherapy but incurable

17
Q

What classifies a non hodgkin lymphoma to appear as high grade?

A

Aggressive, fast-growing Require combination chemotherapy Can be cured

18
Q

How should follicular lymphoma initially treated?

A

Leave it and wait if not causing problems Chemo

19
Q

How should follicular lymphoma initially treated?

A

Leave it and wait if not causing problems Chemo

20
Q

When is Hodgkin Lymphoma’s peak onset?

A

1st peak = 15-35 2nd peak = later in life

21
Q

How should Hodgkin Lymphoma be treated?

A

Combination chemo +/- radiotherapy Monoclonal antibodies Immunotherapy

22
Q

How many lymphomas are Hodgkins lymphoma?

A

30%

23
Q

How many Non-Hodgkin lymphoma’s are B cell in origin?

A

90%

24
Q

Outline Binet classification of CLL

A

Immunology and Haematology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions