Haemostasis Flashcards
What does normal blood contain?
Plasma Platelets RBCs Heparin TFPI Thrombomodulin Coagulin Factors Nitric Oxide Prostacyclin Teflon
How does bleeding stop?
When a clot forms using platelets, vWF and coagulation factors
Clot remains confined to the site of injury natural anti-coagulants
What signals activates coagulation signals?
Abnormal surface proteins
Presence of physiological activator
What do clotting signals allow for?
The resting state becomes activated resulting in platelets and coagulation factors
What is the role of platelets in haemostasis?
To adhere glycoproteins (GP 1b and 1a), Activation of cyclo-oxygenase through cell surface receptions
Aggregation via throboxane A2
Provide phospholipid surface for co-agulatio
Platelet plug formation
What is the commonest bleeding disease?
von Willebrand’s disease
What does vWB factor bind to?
Collagen, platelets and factor A
What does a deficiency in factor IX lead to?
haemophilia B
What does a deficiency in factor VIII?
Haemophilia A
Name some natural anticoagulants?
TFPI, Protein C and S, Antithrombin
What are the risk factors for arterial thrombosis?
Obesity Hypertension Hyperlipidaemia Hypercholestrolaemia DM
What are the risk factors for venous thrombosis?
Pregnancy
Cancer
Immobility
What are the activators of plasminogen?
TPA
U-PA
What are the inhibitors of plasminogen?
PA1-1
PA1-2
What are the inhibitors of plasmin?
A2 Macroglobulin
A2 Antiplasmin
