Prevention Flashcards
The critical regulator in the caries process?
Saliva
What disease process is 5x more common than asthma? What is an important regulator?
Caries, saliva
The key to dental caries was discovered by who and when? What was the hypothesis?
WD Miller “Miller time!”, ‘Non-specific plaque theory’ : acid production by bacteria considered for tooth break down. 1890
Clarke in 1924
Discovered strep mutans, could not prove it caused caries
Keyes to S. mutans?
1960- demonstrated S. mutans was the responsible bacteria for caries in humans. Along w/ Strep sobrinus
Cariogenic properties of strep mutans?
Ability to produce acid (primarily lactic acid), aciduricity- ability to withstand acidic environment, adherence to teeth (sticky glucans)
MS is necessary and sufficient to cause caries. T/F
F. MS is necessary but not solely sufficient for dental caries
MS acquisition and transmission: how does classic data regarding acquisition differ from new data?
1) Old: Colonization after eruption of teeth vs new:colonization may occur at birth, tongue fissures as a niche. 2)Older: MS is a poor biofilm competitor, if S. sanguis colonizes first there is less S. mutans. 3)Old: Vertical transmission, >70% New: horizontal and vertical 4) New: Early MS acquisition assoc w/Bohn’s nodules and high maternal levels
Factors associated with MS acquisition
Sweetened fluids taken to bed, frequent sugar exposure, snacking, sharing foods w/adults, maternal MS levels (Wan et al 2003)
Factors associated with non-colonization of MS
Multiple courses of antibiotics and frequent toothbrushing
Prevention of Transmission–study by? effects of interventions?
(Soderling 2000) 1. Xylitol gum 2. CHX varnish 3. FV –xylitol lowest numbers of infants colonized by MS at ages 2,3, and 6
Lactobacilli and relationship to caries?
Found in large #s of children, considered opportunistic, not initatiors, good indicator of CHO intake, # increases after DEJ is invaded
Children w/S-ECC have more or less microbial diversity?
Less diversity, w/a higher frequency of C albicans
Hopewood House Diet study- describe? Results?
Diets devoid of sugar and white flour, extremely low dental caries (1947)
Vipeholm Vive - Describe?
- Sugar consumption at meals = slight increase 2. Sugar between meals: marked increase 3. Sugar in sticky candies: greatest caries activity 4. Increased caries risk from increased frequencey of ingestion; decreases with less frequency 5. Caries activity differs among individuals.
Glucan- describe? Importance?
Adhesion properties make it difficult to disrupt the biofilm, inhibits diffusion properties of biofilm, reduces buffering capacity of saliva, inhibits transport.
Fructan- describe?
Lesser role than glucan, intracellular can be used by MSas energy source.
Fructose, sucrose, glucose, raw starch, soluble starch, refined starch, and their relative pH changing abilities?
Soluble starch and refined starch can be broken down by salivary amylase into sugars. Least acidogenic: raw starch. Frucose/glucose equally effective as sucrose.
At what pH, begins demineralization? What is the curve called?
Stephan Curve, below 5.5 pH begins demineralization.
What food factors have a protective effect?
Fat content is protective, flavonoids in apples/cranberries-antibacterial, masticatory stimulus, cheese prevents enamel demineralization
Sohn’s beverage study results?
High carbonated bevereages saw the greatest number of caries- Sohn 2006
The relationship between sugar intake and caries is very strong. T/F?
The relationship between sugar consumption is strong in 2/30 papers, vs weak in 18/30. Relationship is much weaker now with modern F- exposure.