Growth and Development Flashcards
Define: Growth Development Hypertrophy Hyperplasia Acretion
Growth: increase in size
Development: increase in complexity
Hypertrophy: increase in size of individual cells
Hyperplasia: increase in # of cells
Acretion: increase in non-cellular material
When is the embryonic period? What is the most prominent structure during this time?What is the fetus susceptible during this period?
First 8 weeks of life The head/face Fetal Alcohol Syndrome Infections (rubella, CMV) Radiation Nutrition deficiency
What are the facial prominences? What do they surround?
The 5 prominences surround the stomoadeum/mouth :
Single median frontonasal (includes the Median nasal process and Lateral Nasal processes)
Paired maxillary process
and paired mandibular process
Branchial arch : 1- mandibular 2 - hyoid 3- glossopharyngeal 4 - plus
1- Meckel’s cartilage, malleus, incus and muscles of masicationg. Trigeminal nerve, maxillary artery
2- Hyoid: stapes, styloid, stapedius, Facial nerve, stapedial artery
- Glossopharyngeal : Greater cornu, stylopharyngeus muscle, glossopharyngeal arter
- Thyroid cartilage, vagus nerve, aorta
The facial processes either fuse or merge. Which ones merge? fuse? What occurs during this? Possible problems?
Merge (median nasal process-philtrum/tip of nose/primary palate; Mandibular process-lower lip/mandible; maxillary and mand processes- comissures of the mouth): midline, incomplete separation of these structures, the underlying mesenchyme migrates
Fusion (median nasal and maxillary process-lateral lip and maxilla; Primary palate and palatal shelves- palate): more complex, surface epithelium needs to disintegrate, defects are more likely to occur where processes fuse as opposed to merge
Which branchial arch anomalies are the most common? Examples of?
2nd branchial arch anomalies (90-95%)
These are all soft tissue defects.
1st branchial arch anomalies are next common at 1% and involve hard tissues.
When are facial structures “defined” during in utero development?
What branchial arch is the major contributor to the facial structures?
What nerve, muscle group and cartilage are associated w/ this branchial arch?
- between 3-11 weeks (the embryonic period)
- 1st branchial arch
- Trigeminal nerve, muscles of mastication, meckel’s cartilage
What are three 1st branchial arch syndromes? And one common manifestation?
Pierre Robin Sequence,
Hemifacial microsomia (goldenhar),
Mandibulofacial dysplasia (Treacher Collins)
- Cleft lip/palate
What percentage of branchial arch anomalies are due to the 2nd branchial arch? What types are there?
-What kind of lesions are they? and when do they present?
90-95%
- Type 1: sternocleidomastoid muscle
- Type 2: near the great vessels
- Type 3: near the in/external carotid arteries
- Type 4: (rare) next to the pharyngeal wall
Cystic lesions are commonly found.
Typically present in the 2nd decade of life
Describe the Fetal development period
Begins 9th week in utero to birth
Characterized by more growth than development (size change)
Body grows more rapidly
Ossification begins
Dental anomalies frequently encountered with cleft/lip patients?
Ectopic eruption of maxillary 1st molars (30%)
Supernumerary teeth
morphologic anomalies
missing teeth
Palatal fusion is typically completed by?
11 weeks
Describe the order the palates “zip” together:
Primary palate zips from posterior to anterior
Secondary palate zips closed from anterior to posterior
Submucous palate occurs when?
What are some problems associated with submucous cleft?
The hard tissue closure is incomplete, but the soft tissue is complete.
- Nasal speech due to lack of muscle attachment, increased incidence of otitis media, “tenting” of the soft palate
Describe the triad of the submucous cleft
Bifid uvula
Palatal muscle diastasis
Notch in the posterior surface of the hard palate