Preterm labor Flashcards

1
Q

preterm labor

general

A

When a patient goes into labor and is greater than 20 weeks and less than 37 weeks gestational age
Preterm birth complicates 12% of all pregnancies in US
#1 cause of neonatal morbidity and mortality
Causes 75% of neonatal deaths not due to congenital anomalies

*Clinical criteria of regular uterine contractions accompanied by a change in cervical dilation, effacement, or both, or initial presentation with regular contractions and cervical dilation of at least 2 cm.

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2
Q

preterm labor

RF

A
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3
Q

Preterm labor

Symptoms

A

Symptoms cramping, initially irregular contractions, pressure in the vagina, and low back pain. Clear-to-pink vaginal discharge is not uncommon and is referred to as the mucus plug or “bloody show.” Spotting can also be demonstrated. As symptoms progress, contractions become more regular and the cervix may dilate, efface

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4
Q

Preterm Labor- Workup

A

Cervical exam, fetal monitoring, ultrasound

Fetal Fibronectin
Extracellular matrix protein present at the decidual-chorionic interface
Any disruption of this interface due to subclinical infection or inflammation, abruption, or uterine contractions releases fFN into cervicovaginal secretions, which is the basis for its use as a marker for predicting preterm labor/birth
FFN only collect if patient between 24 - 34wk GA!

Positive result: increased risk of PTB within 7 days
Many false positive rates

Good negative predictive value! If negative, highly unlikely patient will go into preterm labor within 7-10 days

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5
Q

Fetal Fibronectin

A

Symptomatic patients > Negative FFN
Negative predictive value for delivery within…
7d = 99.5%
14d = 99.25
Benefits of a negative test: Less interventions and avoid hospitalizations

Symptomatic patients > Positive FFN
Positive predictable value for delivery within
7d = 12.7%
14d = 16.7%
Benefits of a positive test: identify a group that can be targeted for intervention, opportunity for antenatal steroids, preparation for neonatal care

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6
Q

Preterm Labor- Diagnosis

A

Patients must have regular uterine contractions along with the presence of:
cervical dilation of 2 cm or greater
cervical length less than 20 mm on transvaginal ultrasound
or cervical length of 20–30 mm on ultrasound with positive fetal fibronectin

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7
Q

Preterm Labor- Management

A

Hospitalization

Magnesium for Fetal Neuroprotection

Antenatal Corticosteroids

Tocolytic Therapy

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8
Q

PTL

Tocolysis

A

Reduces strength & frequency of uterine contractions
Not indicated before fetal viability (24 weeks)
Upper limit of use generally 34 weeks
Not indicated for CTX without cervical change

Contraindications
IUFD
Non-reassuring fetal status
Severe preeclampsia
Hemorrhage with hemodynamic instability
Chorioamnionitis
Maternal medical contraindications (agent-specific)

Tocolytics discontinued after 48 hours

Regimens typically used…
24-32 weeks: indomethacin 50-100mg PO or PR x1 🡪 25mg PO Q4-6h
Contraindications: platelet dysfunction/bleeding disorder, hepatic dysfunction, PUD, renal disease

32-34 weeks: nifedipine 30mg PO x1 🡪 10-20mg PO Q4-6h
Contraindications: hypotension, preload-dependent cardiac lesions, LV dysfunction or CHF

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9
Q

Corticosteroids for Fetal lung maturity

A

Corticosteroids for Fetal Lung Maturity
Betamethasone (and Dexamethasone) has been shown to improve fetal lung maturity and reduce neonatal respiratory distress syndrome (RDS) and mortality in offspring. Subsequent trials have shown that ACS also improves circulatory stability in preterm neonates, resulting in lower rates of intraventricular hemorrhage and necrotizing enterocolitis compared with unexposed preterm neonates.

Steroids increase surfactant and promotes growth of T1 & T2 pneumocytes
Improved lung compliance & volume
Improved gas exchange
Increased surfactant production
Induction of enzymes/receptors to enhance absorption of lung fluid

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10
Q

When to consider antenatal corticosteroids…
Meds options

A

Pregnancies 24-34 with risk of PTB within 7 days
Includes PPROM, multiple gestations, + FFN
New data: steroids can be given after 34 weeks for certain situations

When to give “rescue” steroids
Single repeat course if < 34wks and increased risk of PTB within 7 days
>14 days has passed since first course
>2 courses is NOT recommended

Regimens:
Betamethasone 12mg IM Q24h x2 doses
Dexamethasone 6mg IM Q12h x4 doses

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11
Q

Magnesium for Neuroprotection

A

Preterm exposure to magnesium > decreases diagnosis and severity of cerebral palsy
Magnesium only given < 32 weeks

Give it if delivery is likely within 12-24 hrs

Dosing: 6g loading dose&raquo_space; 2g/hour for 12-24 hrs

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12
Q

Preterm Labor Management - Summary

A

A single course of corticosteroids is recommended for pregnant women between 24 weeks and 34 weeks of gestation who are at risk of delivery within 7 days.

Magnesium sulfate reduces the severity and risk of cerebral palsy in surviving infants if administered when birth is anticipated before 32 weeks of gestation.

The evidence supports the use of first-line tocolytic treatment with calcium channel blockers, or NSAIDs for short-term prolongation of pregnancy (up to 48 hours) to allow for the administration of antenatal steroids

ACOG practice bulletin

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13
Q

Cervical Insufficiency/Incompetence

A

Recurrent painless cervical dilation leading to 2nd trimester pregnancy losses

Risk factors
Cervical trauma (previous surgery), congenital cervical abnormalities, history of shortened cervix in pregnancy)

Measure Cervical Length: Measure length of cervix every 2 weeks from 16-24 weeks, only indicated for those at risk of cervical shortening or cervical incompetence.

< 2.5cm = short cervix

Treatment:
Cerclage (history indicated or exam indicated)
Supplemental Progesterone

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14
Q

Fetal Growth Restriction (FGR)

A

Occur in 10% pregnancies
Defined at estimated fetal weight (EFW) < 10%th percentile OR Abdominal circumference measurement < 10 percentile

Various causes
Constitutional
Fetal genetics
Maternal conditions
Hypertensive disorders, placenta insufficiency
Infection

Management: Umbilical artery dopplers
Monitor fetal growth ultrasounds every 2-4 weeks
Monitor NST/ BPP as patients get closer to due date
Timed delivery

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15
Q

Cesarean Section

A

Birth of fetus through laparotomy then subsequent hysterotomy

Indications:
Previous history of cesarean, labor dystocia, preeclampsia, placenta previa, fetal malpresentation (breech), non reassuring fetal status in labor

**Emergency CS: Decision to incision 30 minutes
Fetus delivered in under 5 minutes

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16
Q

Cesarean Pre-op

A

No solid foods 8 hours before
Stop all clear liquids 2 hours before

Neuraxial anesthesia (regional) prefered method
Spinal OR Epidural
General Anesthesia (reserved for specific cases)

Prophylactic Antacid: Single dose minimizes the lung injury risk from gastric acid aspiration
Prophylactic Antibiotics: Single dose first generation cephalosporin is first line

Thromboprophylaxis: Increased risk of VTE at baseline in pregnancy, that risk increases with cesarean delivery as well. Mechanical prophylaxis by sequential compression devices utilized in surgery for ALL patients.

Left lateral tilt: Use wedge to get patient in left lateral decubitus position. Increase venous return, avoids hypotension from IVC compression

Abdominal Skin Prep: 2% Chlorhexidine or Povidone-Iodine

17
Q

Skin to Uterus: The Layers

A

Skin Incision: Most common type Pfannenstiel
Transverse incision 2-cm above the pubic symphysis
12-15cm wide

Subcutaneous tissue (fat) > rectus abdominis fascia (connective tissue) > rectus muscle > peritoneum > vesicouterine serosa > uterus (hysterotomy = uterine incision) > membranes (amniotic sac) > delivery of fetus!

Hysterotomy (two most common incision types)
Low transverse incision
Horizontal incision in the lower uterine segment
Classical incision
Vertical incision into the body of uterus above the LUS (lower uterine segment), reaches the fundus

18
Q

CS

Fetus Delivery

A

Vertex
Insert hand into uterine cavity
Flex fetal head and elevate it to hysterotomy
Fundal pressure applied to expel fetus
Delivery anterior shoulder with downward traction, than posterior shoulder w/ upward movement and body

Breech
Identify fetal lie, multiple techniques
Footling/frank/complete breech
Deliver to the level of the hips > lengthen umbilical cord > wrap w/ moist towel > apply traction over iliac crests & deliver to level of the scapulae > deliver arms w/ the thumb over the scapula and two fingers over the humeri to flex the arms medially > maintain fetal head flexion > use Mariceau-Smellie-Veit maneuver (index and middle finger apply pressure to maxillary prominence)

19
Q

Vaginal Birth After Cesarean Delivery (VBAC)

A

After CS patients may have the option to undergo repeat CS or try vaginal birth
TOLAC: Trial of Labor after Cesarean
VBAC: Vaginal Birth after Cesarean

Patients who attempt TOLAC 70% success rate

Not all patients are allowed to have vaginal births! Previous history of uterine surgery, vertical/ classical uterine incision, active HSV outbreak, hx of open uterine rupture

How do we decide who gets a repeat CS vs vaginal birth?? VBAC Calculator!

20
Q

Vaginal Birth After Cesarean

Common reasons patients choose TOLAC include…

A

Common reasons patients choose TOLAC include…
Future pregnancy plans since multiple cesarean births increase the risk for placenta previa and accreta spectrum
Family obligations that make a speedy return to normal activities postpartum desirable
Desire to experience labor and vaginal birth
Desire for their partners’ greater involvement in labor and birth

Common reasons patients choose repeat CS include…
Scheduling convenience
Ease of arranging a procedure for permanent contraception at the time of birth
Fear of failed trial of labor and emergency cesarean birth
Avoidance of labor pain and labor in general
Hospital policies restricting access to TOLAC