ectopic/ovarian torsion Flashcards

1
Q

Ectopic Pregnancy

general

A

Implantationof a fertilized egg (embryo) outside the uterine cavity

Epidemiology
3rd-leading cause of maternalmortality
Occurs in 1%–2% of all first trimester pregnancies
Diagnosed in ~10% ofpatientspresenting with vaginal bleeding and abdominalpainin early pregnancy

Etiology
Can occur when the fertilized egg does not enter the uterine cavity by way of thefallopian tubeby the 5th to 6th day of gestation

Caused by:
Disorders of theovulationmechanism
Blockage of theembryo’s tubal passage…affected by congenital anomalies, acquired tubal obstructions, and disruption of ciliary activity or tubemotility

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2
Q

ectopic pregnancy

RF

A

Pelvic inflammatory disease(50% of cases, increases risk 3x)
Adhesionsafter tubal surgery (25% of cases)
Assisted reproduction (in vitro fertilization(IVF))
Prior ectopic pregnancy
Abnormal endometrium (endometriosisor fibroids)
Congenital malformation of theuterus(bicornuateuterus)
Smoking
Advanced age (> 35 years old)
Intrauterine device/oral contraceptives (if pregnancy occurs despite their use)

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3
Q

ectopic

Locations of Implantation

A

> 95% within thefallopian tube
3% in the ovary
1% in the peritoneal cavity (abdominal)
< 1% in thecervix
Combined intrauterine and extrauterine pregnancy may occur rarely

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4
Q

Ectopic pregnancy

clin man

A

General pregnancy symptoms
Breast enlargement and tenderness
Secondary amenorrhea
Morning sickness
May present as anacute abdomen
Sudden, severe, lower abdominal or pelvicpain
Pain may be more diffuse if there is blood in the abdominal cavity
If painradiates toward the shoulder → sign of tubular rupture
Rupture can cause significant internal bleeding → leading to hypovolemicshock

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5
Q

ectopic pregnancy

PE

A

History and clinical examination
Patients may report a missed or irregularlast menstrual period

Vital signs
Tachycardia and hypotension in the case of rupture

Abdomen
Abdominal rigidity
Rebound tenderness and/or guarding

Pelvis
Cervical motion tenderness (differentiate from pelvic inflammatory disease (PID))
Closedcervix
Adnexal tenderness
Palpable adnexalmass (10%–20% of cases)

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6
Q

ectopic

labs

A

Medical Commandment!
Thou shall perform a pregnancy test on all women of reproductive age who present with abdominal pain!
Urine or serum β-hCG (qualitative → quantitative)
Generally lower than expected
If followed over 2 days…plateau rather than doubling every 2 days

Type and screen
Blood type and Rh factor
Rh negative → RhoGAM is required

Complete blood count (CBC)
Anemia/evidence of hemorrhage

To evaluate for other causes of acute abdominal pain: liver function tests(LFTs), basic metabolic panel(BMP), urinalysis (UA)

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7
Q

ectopic preg

Diagnosis

A

US
Normal pregnancy
At 5–6 weeks gestation → a gestational sac and yolk sac are present within theuterus (intrauterine pregnancy)
+*Ectopic pregnancy findings
An empty uterine cavity without an amniotic sac **

β-hCG of 6,500 mIU/mL with an empty uterine cavity by transvaginal US is highly suspicious for ectopic pregnancy
Enlargement of thefallopian tubewith an amniotic sac
Case of tubal rupture, free fluid (blood) is present in thepouch of Douglas

Diagnosis can be further confirmed bylaparoscopy

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8
Q

ectopic pregnancy

differentials

A

Mnemonic “HAIKU POEM” can help you remember the differential diagnoses of an ectopic pregnancy

Non-gynecological causes: HAIKU
H:Hepatitis
A:Acute abdomen
I:Intestinal Inflammation (appendicitis, sigmoiddiverticulitis)
K:Kidney stone
U:Urinary tract infection

Gynecological causes:POEM
P:Pelvic inflammatory disease
O:Ovarian disease (cyst rupture, torsion, polycysticovaries)
E:Endometrial diseases (endometriosis,hyperplasia)
M:Miscarriage/spontaneous abortion

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9
Q

ectopic

Surgical management

A

Can be expectant, medical, or surgical depending on the patient’s condition, hCG trend, and maternal/fetal factors

Surgical (EMERGENCY) management
Assess and stabilize ABCs (airway, breathing, circulation)
Giveintravenous fluidsto compensate for blood loss
Transfusion if blood loss is significant

If the patient is Rh-negativeblood type
Administer RhoGAM
to prevent Rh incompatibility in future pregnancies

Laparoscopy → salpingostomy or salpingectomy
Size of the ectopic pregnancy and whether or not it has ruptured

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10
Q

ecoptic

medical management
Indications

A

Administration of methotrexate 50 mg/m2IM to induce a medicalabortion
Must monitor the patient’s β-hCG levels to 0
Reserved for patients that meet the following:
Hemodynamically stable
Normal liver function
Normal renal function
Pregnancy sac < 3.5 cm and no fetal cardiac activity on ultrasound

**Use of methotrexate in an unstable patient is absolutely contraindicated!**
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11
Q

ectopic pregnancy

Expectant management

A

Reserved for patients who meet the following:
Asymptomatic
No evidence of extrauterine sac/masson ultrasound
Low and decreasing serum β-hCG (≤200 mIU/mL)
Agreeable to close follow-up

Steps include:
Monitoring the pattern of serial β-hCG levels → levels should decline

Giving strict return for follow-up instructions to ensure that β-hCG is monitored

Abandoning expectant management if significant abdominal pain develops or β-hCG increases or fails to decline

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12
Q

Ovarian Torsion/ Adnexal Torsion

general

A

SURGICAL EMERGENCY
Ovaries twist along their axis, with or without involvement of the fallopian tubes, leading to partial or complete obstruction of the arterial blood flow and causing ischemia

Epidemiology:
More common in women of reproductive age because of the regular formation of physiologiccysts
More commonly affects women withovaries> 5 cm
Ovarian cysts and tumors (found in > 85% of cases)
Women undergoing fertility treatments
Polycystic ovarian syndrome (PCOS)
Pregnancy

Right ovarian torsion > Left ovarian torsion (mobility of the left ovary is limited by the sigmoidcolon)

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13
Q

ovarian torsion

RF

A

Age
Reproductive age
Ovarian enlargement (particularly by a benign mass/tumor)
Benign tumors are more likely to cause torsion than malignant tumors
Severity of the torsion is determined by the size of the mass/tumor
Pregnancy
Highest risk during the 1st trimester
Congenital abnormalities (elongation offallopian tubes)
A history of pelvic surgery (adhesions)

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14
Q

ovarian torsion

patho

A

Ovarian or tubo-ovarian torsion involves the following sequence of events:

Twisting along the ovarian axis (suspensory ligament or utero-ovarian ligament)
Compression/blockage of the venous and lymphatic drainage from theovaries
Local edema of the ovary,fallopian tubes, and supportive ligaments
Compression/blockage of the arterial supply of theovaries
Ischemia, followed by necrosis of the ovarian tissue
Local hemorrhage from friable necrotic tissue

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15
Q

ovarian torsion

Clin man

A

Sudden, severe lower abdominal/pelvicpain

Nausea and vomiting
Common
May be continuous or appear in waves

Fever (late finding) → ovary is undergoing necrosis or rupture

Abnormal vaginal bleeding and discharge might be present if associated with rupture or an abscess

Physical examination looking for:
Abdominal guarding/rebound pain
Localizedpainupon palpation
Unilateral tender adnexalmass

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16
Q

ovarian torsion

labs

A

High index of clinical suspicion based on symptoms
Other common causes ofpelvic pain need to be ruled out
What should be on your differential?

Laboratory tests
Qualitative hCG → Quantitative hCG
CBC with differential
Often normal
Leukocytosis in cases of rupture
Anemia in cases of hemorrhage

17
Q

ovarian torsion

imaging
Common findings

A

Imaging
Pelvic ultrasonography with Doppler
Transvaginal US is better than transabdominal US
Often nondiagnostic
NormalDopplerflowdoes not exclude torsion

Common findings:
Asymmetrical, enlarged ovary
Decreased/absent Doppler flow
Whirlpool sign – thickened vascular pedicle
Intraperitoneal fluid → leakage of interstitial fluid from the twisted ovary/fallopian tube

CT abdomen and pelvis is used to rule out other abdominal conditions (appendicitis, diverticulitis, etc.)

18
Q

ovarian torsion

Tx

A

STAT Surgical Exploration
Prompt and early resolution of the torsion to preserve fertility

Laparoscopy/laparotomyis the gold standard for the diagnosis of ovarian torsion (direct visualization by the surgeon)
Preferred approach:laparoscopy
Alternative:laparotomy

Viability of the ovary is evaluated by the surgeon
Cystectomy can be performed for a benign cyst
Salpingo-oophorectomy is preferred in post-menopausal women, and required for malignant tumors, nonviable or necrotic tissue

Ifmalignancyis suspected, consultation with a gynecologic oncologist is recommended

19
Q

ovarian torsion

Laparoscopic oophoropexy

A

Fixate the detorted ovary +/- contralateral ovary to the pelvic side wall, back of uterus, or ipsilateral uterosacral ligament