Pressure and Flow in Arteries and Veins Flashcards

1
Q

What is measurement of arteriolar pressure done by?

A

Auscultation of Karotkoff sounds using spygomanometer and stephoscope

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2
Q

What are the advantages of auscultation of Korotkoff sounds using sphygomomanometer and stephoscope?

A

Non-invasive

Cheap

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3
Q

What are disadvantages of auscultation of Korotkoff sounds using sphymomanometer and stephoscope?

A

Accuracy

Discontinuous

Needs care

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4
Q

What do elastic arteries act as?

A

Pressure reservoirs that damp down pressure variants

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5
Q

What is the pressure wave affected by?

A

Stroke volume

Velocity of ejection

Elasticity of arteries

Total peripheral resistance

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6
Q

What is normal arteriolar pressure?

A

120/80mmHg

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7
Q

How does normal arteriolar pressure change with age?

A

Increases

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8
Q

How does pressure and flow change from arteries to veins?

A

Pressure falls through the vascular tree:

Small drop through arteries (from about 95 to 90mmHg)
Large drop through arterioles (from about 90 to 40mmHg)
Pressure is already low when blood gets to capillaries
Leaves a small pressure difference pushing blood back through the veins (about 20 to 5mmHg)

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9
Q

Why is there only a small drop in pressure through arteries?

A

Low resistance conduit

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10
Q

Why is there a large drop through arterioles?

A

Resistance vessels

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11
Q

Why is it important that the blood pressure is low once it reaches capillaries?

A

They are thin walled

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12
Q

What is the small pressure difference that pushes blood back through the veins called?

A

Systemic filling pressure

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13
Q

What is the systemic filling pressure?

A

Small pressure pushing blood back through the veins

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14
Q

How does pulmonary circulation pressure compare to systemic?

A

1/5 the size

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15
Q

What is the velocity of blood flow related to?

A

Total cross section (fastest in aorta and vena cava, slowest in capillaries)

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16
Q

Where is blood flow the fastest?

A

Aorta and vena cava

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17
Q

Where is blood flow the slowest?

A

Capillaries

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18
Q

How does velocity of blood flow relate to total cross sectional area?

A

Greater the total cross sectional area the smaller the velocity

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19
Q

What can central venous pressure be estimated by?

A

Jugular collapse

20
Q

How does the blood pressure drop as it goes through arteries?

A

Drops from 95 to 90mmHg

21
Q

How does blood pressure drop as it goes through arterioles?

A

From 90 to 40mmHg

22
Q

What is the value os systemic filling pressure?

A

20 to 5mmHg

23
Q

What is the pressure like in veins?

A

Low so difference in pressure driving blood back to heart is low

24
Q

What are the complications of veins being distensible and collapsible?

A

Flow is affected by external influences such as:

Gravity
Skeletal muscle pump
Respiratory pump
Venomotor tone
Systemic filling pressure

25
Why do external factors affect flow in veins?
They are distensible and collapsible
26
What are examples of external factors that affect flow in veins?
Gravity Skeletal muscle pump Respiratory pump Venomotor tone Systemic filling pressure
27
What can gravity cause in terms of flow through veins?
Venous distension in legs Venous collapse in neck
28
What does venous distension in legs cause?
Decreases EDV Decreases preload Decreases stroke volume Decreases cardiac output Decreases mean arteriolar pressure
29
What can the venous collapse in the neck be used to estimate?
Central venous pressure
30
What are examples of skeletal muscle pump impacting venous flow?
Rhythmic vs static exercise Hot guardsmen Deep vein thrombosis Varicose veins
31
What is venomotor tone?
State of contraction of the smooth muscles surrounding the venules and veins
32
What is the state of contraction of the smooth muscles surrounding the venules and veins valled?
Venomotor tone
33
How does gravity impact the flow of blood through veins?
Greater pressure at the bottom of the body
34
What does clotting involve?
Formation of a platelet plug Formation of a fibrin clot
35
What is converted into fibrin?
Fibrinogen
36
What is fibrinogen converted into?
Fibrin
37
What catalyses the reaction of fibrinogen to fibrin?
Thrombin
38
What is blood in the capillaries in danger of due to travelling so slow?
Clotting
39
What works hard to prevent blood clotting through capillaries?
Epithelium
40
What are some anti-clotting mechanisms of the epithelium?
Stops blood contacting collagen Produces prostacyclin and NO Produces tissue factor pathway inhibitor (TFPI) Expresses thrombomodulin Expresses heparin Secretes tissue plasminogen activator
41
How does stopping blood contacting collagen prevent clots?
No platelet aggregation
42
How does producing prostacyclin and NO prevent clots?
Both inhibit platelet aggregation
43
How does producing tissue factor pathway inhibitor prevent clots?
Stops thombin production
44
What does TFPI stand for?
Tissue factor pathway inhibitor
45
How does expressing thrombomodulin prevent clots?
Binds to thrombin and inactivates it
46
How does expressing heparin prevent clots?
Inactivates thrombin
47
How does secreting plasminogen activator prevent clots?
Catalyses the reaction of plasminogen to plasmin, and plasmin digests the clot