Presentation of kidney disease Flashcards

1
Q

what are the possible features of kidney disease presentation

A
asymptomatic 
loin pain/ urinary symptoms 
haematuria (microscopicm painless macroscopic haematuria) 
proteinuria
hypertension 
AKI
CKD
nephrotic syndrome 
nephritic syndrome
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2
Q

what do the majority of people with kidney disease present with

A

are asymptomatic- will be an incidental finding

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3
Q

what causes systemic symptoms in kidney disease

A
underlying disease (DM, CTD, vascular disease)
or effects of loss of kidney function (uraemic, fluid retention, bone pain)
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4
Q

what happens when the kidney stops excreting urea

A

uraemia

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5
Q

what are the can be caused by uraemia

A

pericarditis, encephalopathy, neuropathy, asterixis, gastritis

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6
Q

what happens when the kidney stops maintaing fluid balance

A

fluid retention- oedema, ascites

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7
Q

what happens when the kidney stops maintaining electrolyte balance

A

hyperkalaemia- arrhythmia

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8
Q

what happens when the kidney stops maintaining acid- base balance

A

metabolic acidosis

kussmauls respiration

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9
Q

what happens when the kidney stops metabolising Vit d and excreting phosphate

A

renal bone disease (bony pain) and vascular calcification

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10
Q

what happens when the kidney stops producing erytropoietin

A

anaemia

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11
Q

what happens when the kidney stops excreting drugs

A

can get drug toxicity - digoxin, gabapentin

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12
Q

what happens when the kidney stops working as a barrier to loss of proteins

A

proteinuria and nephrotic syndrome

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13
Q

how might asymptomatic patient’s get diagnosed with kidney disease

A
dipstix (microscopic haematuria &/or protein uria)
reduced eGFR on biochem screen 
raised BP
abdo imaging 
screening because of family history
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14
Q

what local/ renal signs and symptoms might patients present with

A
loin/ abdo pain
macroscopic haematuria 
UTI
arterial bruits 
palpable kidneys
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15
Q

what questions should you ask in the systemic enquiry

A
appetite & weight loss
nausea & vomiting
dyspepsia
dyspnoea
urinary symptoms
	e.g. frequency, urgency, hesitancy, polyuria & nocturia
joint pains & arthralgia
skin rashes
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16
Q

how do NSAIDs affect GFR

A

reduce pressure within the glomerulus, reducing filtration rate
can also cause ASK by causing an allergic reaction within the kidney

17
Q

what drugs should you ask about in a history (in patient with kidney disease)

A

ACEi, ARB, diuretics, NSAIDs, gentamicin, trimethoprim, penicillin, PPIs, radiology contrast, herbal remedies

18
Q

what are the systemic signs related to an underlying disease causing kidney disease

A

pyrexia, skin rash, heart murmurs, consolidation, ENT, retinopathy (DM & HBP), neuropathy, arterial bruits, rheumatoid

19
Q

what are the systemic signs related to an loss of kidney function

A

pallor, arrythmia, pericardial rub (pericarditis life threatening comp of kidney disease), rasied JVP, lung crepitations, gout

20
Q

what is accelerated hypertension

A

medical emergency
diastolic BP > 120 mmHg
papilloedema
end organ decompensation (encephalopathy, fits, cardiac failure, acute renal failure)

21
Q

what does accelerated hypertension look like on fundoscopy

A

papilloedema
flame haemorrhages
cotton wool spots

22
Q

what nail changes in renal disease

A
leukonychia 
splinter haemorrhages (come from kidneys after infection)
23
Q

is gout caused by/ causes renal disease

A

both
may cause renal impairment (renal stones)
or be a consequence of renal impairment

24
Q

what possible skin changes in renal disease

A
gouty trophi
vasculitis rash (vasculitis (HSP), acute glomerulonephritis)
malar rash (SLE)
25
Q

what causes myogloin to be in urine

A

e.g. a crush injury when someone has been lying in same position for ages get Rhabdomyolosis were muscles break down

26
Q

what do the parameters of urinalysis tell you

A
specific gravity- urine concentration
haematuria- haemoglobin, RBC, myoglobin 
proteinuria 
pH(4.5-7). alkaline  = distal renal tubular acidosis. UTI
leukocyte esterase/ nitrates= UTI
27
Q

what are the levels of urine protein

A

asymptomatic low grade <1g/day
heavy proteinuria 1-3 g/day
nephrotic range >3 g/day

28
Q

when are urinary casts formed

A

when low urine out put/ low pH

29
Q

what causes a hyaline cast

A

usually benign (normal)

30
Q

what causes a red cell cast

A

always pathological (associated with nephritic syndrome)

31
Q

what causes a leucocyte cast

A

infection or inflammation

32
Q

what causes granular cast

A

indicative of chronic disease

33
Q

what ECG results for severe hypertension

A

LVH and strain

34
Q

what ECG in hyperkalaemia

A

peaked T waves (tall tented)

35
Q

what is acute kidney disease

A

decline in GFR over hours/ days/ weeks

can be with/without oliguria or normal/ impaired baseline renal function

36
Q

what is oligouria

A

<400 ml urine/ day

37
Q

what is nephrotic syndrome

A

triad of sy/si due to glomerular disease:
-proteinuria >3g/day (mostly albumins)
-hypoalbuminaemia
-oedema (everywhere but esp periorbital)
(hypercholesterolaemia- liver working overtime to produce more albumin to compensate for loss)

often have normal renal function

38
Q

what is nephritic syndrome

A

si/sy of glomerulonephritis

  • AKI
  • oliguria
  • oedema/ fluid retention (not as bad as nephrOtic syndrome)
  • hypertension
  • active urinary sediment
  • RBC’s, granulae casts, proteinuria