PRENATAL DIAGNOSIS

Question 1

Risk Factors For Aneuploidy

Answer 1

Maternal age- risk increases with maternal age

Presence of birth defects or soft markers on ultrasound

Prior pregnancy affected by aneuploidy or genetic disorder.

Family history of aneuploidy

Question 2

Down’s Syndrome Associations

Answer 2

Decreased levels of maternal serum alphafetoprotein (AFP)

Decreased levels of unconjugated estriol (uE3)

Elevated levels of human chorionic gonadotropin (hCG)

Question 3

FIRST-TRIMESTER SCREEN components
(13-16wks)

Answer 3

Nuchal Translucency

Beta hCG

Plasma Protein A

Question 4

Second Trimester Screen components
(15-22wks)

Answer 4

hCG

Unconjugated Estradiol

Inhibin A

AFP