pregnancy and reproduction Flashcards
hormones of pregnancy: explain the physiological roles of specific hormones in pregnancy, their sites of synthesis and how their circulating concentrations change throughout pregnancy
diagram of hormone changes during pregnancy
diagram; human placental lactogen involved in metabolism
where are progesterone and oestrogen produced in first 40 days of pregnancy
corpus luteum in maternal ovary
what stimulates progesterone and oestrogen production in first 40 days of pregnancy, what produces it and where does it act, what does it do
hCG produced by trophoblasts, acts on LH receptors; used to maintain corpus luteum to continue making progesterone; hCG injections to promote ovulation
what is progesterone and oestrogen essential for in first 40 days of pregnancy
developing fetoplacental unit
what hormones do progesterone and oestrogen inhibit
maternal LH and FSH by negative feedback
what provides progesterone and oestrogen from day 40 of pregnancy
placenta, so hCG levels decrease
diagram showing progesterone and oestrogen production during pregnancy
diagram
what are main sources of substrate made into oestrogens
maternal and foetal DHEAS
what 6 maternal hormones increase during pregnancy
ACTH, and therefore adrenal steroids, prolactin (check visual fields to determine whether prolacintoma in pituitary during pegnancy), IGF1 (stimulated by placental GH-variant), iodothryonines (hCG shares similar receptor to TSH), PTH related peptides (rasies blood Ca2+ to ensure enough through to foetus)
what 3 maternal hormones decrease during pregnancy
gonadotrophins, pituitary GH, TSH (can take tablets to replace)
