Pregnancy

Question 1

Molar pregnancy is a _ disease of pregnancy

Answer 1

Molar pregnancy is a trophoblastic disease of pregnancy
* Placental tissue goes rogue

Question 2

_ are the trophoblastic cells that make beta-hCG

Answer 2

Syncytiotrophoblast are the trophoblastic cells that make beta-hCG

Question 3

_ are the trophoblastic cells that make villi in the uterus

Answer 3

Cytotrophoblasts are the trophoblastic cells that make villi in the uterus

Question 4

A complete mole occurs when a _ ovum joins with _ sperm

Answer 4

A complete mole occurs when an enucleated ovum joins with 1 sperm –> paternal DNA gets duplicated

Question 5

The karyotype of a complete mole will be _ or _

Answer 5

The karyotype of a complete mole will be 46XX or 46XY
* The most common form is 46XX

Question 6

Complete moles are associated with _ B-hCG levels

Answer 6

Complete moles are associated with very high B-hCG levels

Question 7

A partial mole occurs when a _ ovum joins _ sperm

Answer 7

A partial mole occurs when a normal ovum joins 2 sperm

Question 8

(Complete/Partial) moles are associated with higher B-hCG levels

Answer 8

Complete moles are associated with higher B-hCG levels

Question 9

(Complete/Partial) moles are associated with more hydropic villi (chorionic villi)

Answer 9

Complete moles are associated with more hydropic villi (chorionic villi)

Question 10

Partial moles will have one of the following karyotypes:

Answer 10

Partial moles will have one of the following karyotypes: 69XXX, 69XXY, 69XYY

Question 11

_ mole will cause mild increase in B-hCG and minimal hydropic villi and proliferation

Answer 11

Partial mole will cause mild increase in B-hCG and minimal hydropic villi and proliferation

Question 12

(Complete/Partial) moles have a greater risk of choriocarcinoma

Answer 12

Complete moles have a greater risk of choriocarcinoma

Question 13

(Complete/Partial) mole involves placental tissue taking up the entire uterine cavity leading to an enlarged uterus

Answer 13

Complete mole involves placental tissue taking up the entire uterine cavity leading to an enlarged uterus

Question 14

A (complete/partial) mole will result in a normal size uterus but may present with fetal parts

Answer 14

A partial mole will result in a normal size uterus but may present with fetal parts

Question 15

Moles will classically present with the following symptoms:

Answer 15

Moles will classically present with the following symptoms:
* Morning sickness
* Pelvic discomfort
* First semester vaginal bleeding
* Increased uterine fundus size for gestational age
* Grape-like mass
* High B-hCG > 100

Question 16

Molar pregnancy may result in _ first semester vaginal bleeding

Answer 16

Molar pregnancy may result in prune juice first semester vaginal bleeding

Question 17

How will a mole present on ultrasound?

Answer 17

Central heterogeneous mass with multiple discrete anechoic spaces
* Complete mole: snowstorm, grape cluster, honeycomb

Question 18

_ is malignancy of trophoblastic tissue in the mother or baby during or after pregnancy

Answer 18

Choriocarcinoma is malignancy of trophoblastic tissue in the mother or baby during or after pregnancy
* Increase B-hCG, no chorionic villi, +/- bilateral theca lutein cysts

Question 19

Choriocarcinoma is associated with _ metastasis to the _ (most commonly)

Answer 19

Choriocarcinoma is associated with cannonball metastasis to the lungs (most commonly)
* Hematogenous spread to the lungs
* Presents with SOB and hemoptysis

Question 20

We treat choriocarcinoma with _

Answer 20

We treat choriocarcinoma with methotrexate
* Very treatable