Preg: Drugs Flashcards
1
Q
Causes of birth defects and %
A
- Genetic (20-25%)
- Exogenous, potentially preventable (10%)
- Unknown (65%)
2
Q
During pregnancy, which weeks are most critical for development
A
2 to 8 weeks
3
Q
When will a teratogneic drug cause an effect
A
- If present above threshold concentration
- If present during critical stage of embryonic development
4
Q
In which animals was Thalidomide teratogenic?
A
In rabbits and monkeys only.
(Not rats)
5
Q
How many animals need to be used to test a new drug for teratogrnicity?
A
2 species
