Prednisone

Question 1

Prednisolone MOA

Answer 1

glucocorticoids diffuse across cell membrane, bind w/ receptor then enter nucleus & interacts w/ DNA

Question 2

Effects of prednisolone

Answer 2

anti-inflamm: inhibits production of most cytokines and pro-inflamm mediators

inhibit innate immunity- supresses phagocytic fuction on neutrophils an mfs

Decreased # of circulation T cells

Decrease IgG and IgA?

Question 3

Predisolone Uses

Answer 3

prophylaxis of transplanted organ rejection

autoimmune disease

inflamm disorder

allergic conditions

malignancies

Question 4

Long Term Adverse Effects

Answer 4

cataracts, glaucoma

hyperlipidema leading to atherosclerosis

HTN

Osteoporosis

Hypothalamic-pituitary-adrenal insufficiency

Heightened risk of opportunistic infections

Question 5

Short Term Adverse Effects

Answer 5

SKin thinning, purpura (bruising)

cushingoid appearance (moon face, buffalo hump, big belly, weight gain

HTN

GI: gastritis, ulcers, increased appetite

Neuro-psychiatric- euphoria, insomnia, psychosis, depression, mania

Hyperglycemia leading to Diabetes

Heightened risk of opportunistic infections

Question 6

Prednisolone Monitoring Parameters

Answer 6

Blood BP

CMP- check glucose specifically

Lipids

Long-term:

• opthalmic exam (cataracts, ocular pressure)
• DEXA scan (bone density)

Question 7

Prednisolone Patient Instructions:
How to take
When to take
Watch for
When to call/go to ER

Answer 7

How; take w/ meals

When: morning &/or noon

Watch: psychosis, high blood sugars, increased BP, vision disturbances

When to go: pounding HA, chest pain, SOB, psychosis, HTN

Question 8

What is an immunosuppressive Drug?

Answer 8

drug used to prevent the production of abys

mainly used in autoimmune disorders and organ transplant