Immuno Therapy

Question 1

IVIG (IgG)

• indications
• CI
• SE

Answer 1

Indications-primary & secondary immune deficiency

• autoimmune disorders (x-linked agammaglobulinemia, hypogammaglobulinemia, SCID, Common variable)
• inflamm disorder
• effects may last 2wks-3mo

CI
-people w/ IgA deficiency (low IgA d/t body destroying it, if you give IgA to these pts their body will have an anaphylactic rxn b/c body recognizes IgA as non-self)

• SE
• fever
• chills
• malaise
• HA
• dyspnea
• urticaria (rash)
• anaphylaxis in IgA deficient ppl
• thrombosis
• hemolysis
• kidney injury

Question 2

Hyperimmune globulin

• indications
• CI
• SE

Answer 2

Indications: short lived immunity against a specific organism such as Hep B, Rabies, Tetanus, Varicella Zoster
*gives immediate passive immunity

CI:
-not administered to those w/ IgA deficiencies

SE:
-decreased efficacy of live vaccines

Question 3

Hepatitis B Immune Globulin

• Indications
• CI
• SE

Answer 3

Indications:
-past exposure, prophylaxis to Hep B

CI
-allergy to Human Immune Globulin

SE
-allergic rxn
=back pain
-discomfort
-HA
-muscle pain
-nausea
-pain/bleeding at injection site

Question 4

What is immunotherapy?

Answer 4

treatment that uses your body’s own immune system to help fight cancer

Question 5

Rabies Immune Globulin

• indication
• CI
• SE

Answer 5

indication

• pts that have had rabies exposure
• never had rabies vaccine

CI
-?

SE
-?

Question 6

Tetanus Immune Globulin

• Indications
• CI
• SE

Answer 6

indications:
- uncertain pt hx of tetanus vaccination & has unclean wound

CI

• allergy to tetanus
• IM injection d/t bleeding concerns

SE

• anaphylaxis
• angioedema
• pain or tenderness at injection site
• nephritic syndrome

Question 7

Varicella-Zoster Immune Globlin

• Indications
• CI
• SE

Answer 7

Indications

• post exposure prophylaxis for immunocompromised ppl w/o history of immunity
• newborns of mothers w/ varicella or zoster

CI
-?

SE

• anaphylaxis
• pain at injection site
• chills
• fatigue
• rash
• Nausea
• thrombosis

Question 8

What is Xolair/Omalizumab?

Answer 8

Anti-IgE therapy used for asthma

monoclonal Aby
this medication is used to occupy most/more of the circulating/free IgE antibodies so they do not bind to the cells»>decreasing the allergic response.