Precancerous And Cancerous Lesions Flashcards
Green tea polyphenol is the active ingredient in
Ingenue Mebutate
The topical treatment for AKs that acts by activating toll like receptor 7 is:
Imiquimod
A hyperkeratotic AK on the scalp has been treated with cryosurgery on 2 previous occasions within the past 3 months. Your next action should be
Biopsy
The type of BCC that appears like a depressed area of induration and may be mistaken for a scar describes:
Morpheaform
The type of BCC that upon histology palisading and clefting is a prominent feature
Nodular
The most common type of BCC
Nodular
A patient presents with a BCC located on the lower back. The lesion is pink, appearing pedunculated smooth papule. What type of BCC does this represent?
Fibroepithelioma
Imiquimod has FDA indication for what type of BCC?
Superficial
A 56-year-old male presents with an 8 mm nodular BCC located on the nose. The best treatment for this is
Mohs surgery
What are potential side effects of vismodegib?
Nausea, weight loss, alopecia
A 68-year-old male patient with advanced BCC has been prescribed Vismodegib. He is currently taking warfarin, lisinopril, metformin, furosemide and rantidine. Which medication would be contraindicated for Vismodegib use?
Rantidine
Most patients with low grade asymptomatic cutaneous B-cell lymphoma should be treated by
Watchful waiting
There is a possible link to the development of cutaneous B-cell lymphomas with which infection agent?
Borrelia
Almost all patients with cutaneous B-cell lymphomas will react positive to which marker?
CD20
What is an important diagnostic histological clue for primary cutaneous margin zone B-cell lymphoma?
Dutcher bodies
What is a diagnostic finding for the diagnosis of sezary syndrome?
Peripheral blood smear demonstrating sezary cells
UV photo carcinogenic starts with what process?
DNA damage
Prolonged chemical exposure to what substance is linked to the development of non-melanoma skin cancer?
Asphalt
True or false: UV exposure early in life has a large influence on development of subsequent skin cancers
True
Solid organ transplant patients have an increased risk of developing skin cancers. Which one has the highest risk of developing?
SqCC
What are characteristics of keratoacanthomas?
Occur mostly in patients with Fitzpatrick skin type 1 and 2, incidence data may not be accurate due to similarities with SqCC and tendency to regress.
The 3rd stage of the more common forms of keratoacanthomas can be described as:
Regression which occurs over several months that causes atrophy and scarring
True or False: Intralesional Methotrexate or 5FU have been shown to be the treatment of choice for the more common singular KA
False
True or False: The damage for UVA rays is indirect, while the damage from UVB rays is direct.
True
The most common subtype of melanoma is
Superficial spreading
Mrs. Jones presents for routine dermatologic exam. On her arm is a 1 cm brown-black 2 toned papule. With questioning, she endorses 2 occasions of spontaneous bleeding from the lesion. You determine a biopsy is warranted. What is the best choice of biopsy technique?
Excisional
Intrinsic risk factors for melanoma include:
atypical appearing nevi, # of regular appearing nevi and hx of melanoma in the past 10 years
Alex is a 32-year-old female recently diagnosed with a 4.7 mm ulceratwd superficial spreading melanoma of the left calf. The T stage of her melanoma is?
T4b
What type of mutation is seen in approximately 50% of cutaneous melanomas?
BRAF
True or False: Checkpoint inhibitors work through the immune system and have direct tumor effect.
True
For a melanoma-in-situ on the cheek of an 88-year-old male, the appropriate surgical margin would be?
0.5 cm peripheral margins
True or False: Melanomas can occur anywhere on the body, including those with little or no history of UV exposure.
True
The most common type of mastocytosis in childhood onset is:
Mastocytoma
The presence of vesicles/bullae may occur in which type mastocytoma?
Childhood onset
One of the most common sites for the adult onset mastocytosis is
Proximal extremities
Elicitstion of an urticaria response when a mastocytosis lesion is stroked is described as
Darier’s sign
A patient with mastocytosis has no clinical signs other than the cutaneous lesions. CbC is normal. What lab test should be obtained and monitored periodically?
Tryptase levels
Bowen’s disease is a term often interchanged for
SqCC-in-situ
Erythroplastic of Queyrat type of SqCC is located where
Penis
Bowenoid papulosa is a type of SQCC-in-situ often associated with which type of HPV?
Type 16&18
Buscke-Lowenstein tumor is located where?
Genitals
Risk factors for SQCC metastasis include what?
Immunosuppression, SqCC developing in scar tissue, poorly differentiated invasive histology
SqCC metastasis is most likely to occur in which organ?
Lung
A female patient in her 60s arrives at a clinic visit extremely concerned about a lesion. She states the lesion is new, rough feeling and has 2 colors. Your decision to biopsy is based on:
Presence of variegated color, new lesion, lack of similar lesions elsewhere and to alleviate the Patient’s concern.
The WHO-EORTC classification system labels Mycosis Fungoids as an
Aggressive Behavior Type
Classic mycosis fungoides accounts for what percentage of all CTCLs?
60%
Early lesions of mycosis fungoides will most likely occur in what areas?
Trunk
Early stages of Mycosis Fungoides may resemble
Eczema, Medication Reaction
A common side effect of topical nitrogen mustard is
Skin irritation
Bexarotene is classified as a
Retinoid
10-year survival rate for patients with CTCL that has limited patch/plaque lesions is approximately
97%
