Precancerous And Cancerous Lesions

Question 1

Green tea polyphenol is the active ingredient in

Answer 1

Ingenue Mebutate

Question 2

The topical treatment for AKs that acts by activating toll like receptor 7 is:

Answer 2

Imiquimod

Question 3

A hyperkeratotic AK on the scalp has been treated with cryosurgery on 2 previous occasions within the past 3 months. Your next action should be

Answer 3

Biopsy

Question 4

The type of BCC that appears like a depressed area of induration and may be mistaken for a scar describes:

Answer 4

Morpheaform

Question 5

The type of BCC that upon histology palisading and clefting is a prominent feature

Answer 5

Nodular

Question 6

The most common type of BCC

Answer 6

Nodular

Question 7

A patient presents with a BCC located on the lower back. The lesion is pink, appearing pedunculated smooth papule. What type of BCC does this represent?

Answer 7

Fibroepithelioma

Question 8

Imiquimod has FDA indication for what type of BCC?

Answer 8

Superficial

Question 9

A 56-year-old male presents with an 8 mm nodular BCC located on the nose. The best treatment for this is

Answer 9

Mohs surgery

Question 10

What are potential side effects of vismodegib?

Answer 10

Nausea, weight loss, alopecia

Question 11

A 68-year-old male patient with advanced BCC has been prescribed Vismodegib. He is currently taking warfarin, lisinopril, metformin, furosemide and rantidine. Which medication would be contraindicated for Vismodegib use?

Answer 11

Rantidine

Question 12

Most patients with low grade asymptomatic cutaneous B-cell lymphoma should be treated by

Answer 12

Watchful waiting

Question 13

There is a possible link to the development of cutaneous B-cell lymphomas with which infection agent?

Answer 13

Borrelia

Question 14

Almost all patients with cutaneous B-cell lymphomas will react positive to which marker?

Answer 14

CD20

Question 15

What is an important diagnostic histological clue for primary cutaneous margin zone B-cell lymphoma?

Answer 15

Dutcher bodies

Question 16

What is a diagnostic finding for the diagnosis of sezary syndrome?

Answer 16

Peripheral blood smear demonstrating sezary cells

Question 17

UV photo carcinogenic starts with what process?

Answer 17

DNA damage

Question 18

Prolonged chemical exposure to what substance is linked to the development of non-melanoma skin cancer?

Answer 18

Asphalt

Question 19

True or false: UV exposure early in life has a large influence on development of subsequent skin cancers

Answer 19

True

Question 20

Solid organ transplant patients have an increased risk of developing skin cancers. Which one has the highest risk of developing?

Answer 20

SqCC

Question 21

What are characteristics of keratoacanthomas?

Answer 21

Occur mostly in patients with Fitzpatrick skin type 1 and 2, incidence data may not be accurate due to similarities with SqCC and tendency to regress.

Question 22

The 3rd stage of the more common forms of keratoacanthomas can be described as:

Answer 22

Regression which occurs over several months that causes atrophy and scarring

Question 23

True or False: Intralesional Methotrexate or 5FU have been shown to be the treatment of choice for the more common singular KA

Answer 23

False

Question 24

True or False: The damage for UVA rays is indirect, while the damage from UVB rays is direct.

Answer 24

True

Question 25

The most common subtype of melanoma is

Answer 25

Superficial spreading

Question 26

Mrs. Jones presents for routine dermatologic exam. On her arm is a 1 cm brown-black 2 toned papule. With questioning, she endorses 2 occasions of spontaneous bleeding from the lesion. You determine a biopsy is warranted. What is the best choice of biopsy technique?

Answer 26

Excisional

Question 27

Intrinsic risk factors for melanoma include:

Answer 27

# atypical appearing nevi, # of regular appearing nevi and hx of melanoma in the past 10 years

Question 28

Alex is a 32-year-old female recently diagnosed with a 4.7 mm ulceratwd superficial spreading melanoma of the left calf. The T stage of her melanoma is?

Answer 28

T4b

Question 29

What type of mutation is seen in approximately 50% of cutaneous melanomas?

Answer 29

BRAF

Question 30

True or False: Checkpoint inhibitors work through the immune system and have direct tumor effect.

Answer 30

True

Question 31

For a melanoma-in-situ on the cheek of an 88-year-old male, the appropriate surgical margin would be?

Answer 31

0.5 cm peripheral margins

Question 32

True or False: Melanomas can occur anywhere on the body, including those with little or no history of UV exposure.

Answer 32

True

Question 33

The most common type of mastocytosis in childhood onset is:

Answer 33

Mastocytoma

Question 34

The presence of vesicles/bullae may occur in which type mastocytoma?

Answer 34

Childhood onset

Question 35

One of the most common sites for the adult onset mastocytosis is

Answer 35

Proximal extremities

Question 36

Elicitstion of an urticaria response when a mastocytosis lesion is stroked is described as

Answer 36

Darier's sign

Question 37

A patient with mastocytosis has no clinical signs other than the cutaneous lesions. CbC is normal. What lab test should be obtained and monitored periodically?

Answer 37

Tryptase levels

Question 38

Bowen's disease is a term often interchanged for

Answer 38

SqCC-in-situ

Question 39

Erythroplastic of Queyrat type of SqCC is located where

Answer 39

Penis

Question 40

Bowenoid papulosa is a type of SQCC-in-situ often associated with which type of HPV?

Answer 40

Type 16&18

Question 41

Buscke-Lowenstein tumor is located where?

Answer 41

Genitals

Question 42

Risk factors for SQCC metastasis include what?

Answer 42

Immunosuppression, SqCC developing in scar tissue, poorly differentiated invasive histology

Question 43

SqCC metastasis is most likely to occur in which organ?

Answer 43

Lung

Question 44

A female patient in her 60s arrives at a clinic visit extremely concerned about a lesion. She states the lesion is new, rough feeling and has 2 colors. Your decision to biopsy is based on:

Answer 44

Presence of variegated color, new lesion, lack of similar lesions elsewhere and to alleviate the Patient's concern.

Question 45

The WHO-EORTC classification system labels Mycosis Fungoids as an

Answer 45

Aggressive Behavior Type

Question 46

Classic mycosis fungoides accounts for what percentage of all CTCLs?

Answer 46

60%

Question 47

Early lesions of mycosis fungoides will most likely occur in what areas?

Answer 47

Trunk

Question 48

Early stages of Mycosis Fungoides may resemble

Answer 48

Eczema, Medication Reaction

Question 49

A common side effect of topical nitrogen mustard is

Answer 49

Skin irritation

Question 50

Bexarotene is classified as a

Answer 50

Retinoid

Question 51

10-year survival rate for patients with CTCL that has limited patch/plaque lesions is approximately

Answer 51

97%