Practice Questions Flashcards
is promotion of apoptosis a hall mark of cancer
no
is evasion of necrosis a hall mark of cancer
yes
is anoikis promotion a hall mark of cancer
no
is avoiding senescence a hall mark of cancer
yes
is reduced formation of blood vessels a hall mark of cancer
no
Because anabolic steroids can increase the proliferation rate of cells, they would best be
classified as a
tumor promoter
Because a DNA virus can insert new genes into a cell’s genome, it would best be classified
as a
biological mutagen
ultralight is an example of a
physical mutagen
describe why loss of genetic stability is a critical step in carcinogenesis
- Carcinogenesis is initiated through mutations and their progressive accumulation through
promotion/progression can lead to alterations in proto-oncogenes and tumor suppressor
genes that produce a cancer cell. - Mutation rates are intrinsically low due to DNA damage sensor and repair proteins in
healthy cells. - Genomic instability is due to mutations/losses of DNA damage sensors or repair proteins
that make the cell unable to repair DNA damage so that it leads to mutations more often
than for a normal cell. - Over a replicative cycle, cells that have genomic instability yield more rapid mutation rates,
and thus faster carcinogenesis.
is apoptosis evasion a characteristic of cancer
yes
is Dna damage efficiently leads to cell cycle arrest a characteristic of cancer
no
is anoikis evasion to allow circulation in the bloodstream a characteristic of cancer
yes
is high fidelity replication that yields a stable genome a characteristic of cancer
no
is immortalization by overexpression of caspases a characteristic of cancer
no
a heritable change to DNA that cannot be corrected is a
mutagen
cancer is also known as
malignant neoplasia
steroids that increase the rat of cell division are a class of
tumor promoter
______ can activate the intrinsic apoptosis pathway
DNA Damage
which are the products of proto-oncogenes and tumor suppressor genes
PO products: P2,P3
TSG Products: P1, P4
which are protien products of genes that require a minimum of 2 genomic mutations to yield a phenotypic change
P1, P4
which could be a protein product of a DNA tumor virus infection
P2
