Practice Questions

Question 1

is promotion of apoptosis a hall mark of cancer

Answer 1

no

Question 2

is evasion of necrosis a hall mark of cancer

Answer 2

yes

Question 3

is anoikis promotion a hall mark of cancer

Answer 3

no

Question 4

is avoiding senescence a hall mark of cancer

Answer 4

yes

Question 5

is reduced formation of blood vessels a hall mark of cancer

Answer 5

no

Question 6

Because anabolic steroids can increase the proliferation rate of cells, they would best be
classified as a

Answer 6

tumor promoter

Question 7

Because a DNA virus can insert new genes into a cell’s genome, it would best be classified
as a

Answer 7

biological mutagen

Question 8

ultralight is an example of a

Answer 8

physical mutagen

Question 9

describe why loss of genetic stability is a critical step in carcinogenesis

Answer 9

• Carcinogenesis is initiated through mutations and their progressive accumulation through
  promotion/progression can lead to alterations in proto-oncogenes and tumor suppressor
  genes that produce a cancer cell.
• Mutation rates are intrinsically low due to DNA damage sensor and repair proteins in
  healthy cells.
• Genomic instability is due to mutations/losses of DNA damage sensors or repair proteins
  that make the cell unable to repair DNA damage so that it leads to mutations more often
  than for a normal cell.
• Over a replicative cycle, cells that have genomic instability yield more rapid mutation rates,
  and thus faster carcinogenesis.

Question 10

Answer 10

Question 11

Answer 11

Question 12

Answer 12

Question 13

Answer 13

Question 14

is apoptosis evasion a characteristic of cancer

Answer 14

yes

Question 15

is Dna damage efficiently leads to cell cycle arrest a characteristic of cancer

Answer 15

no

Question 16

is anoikis evasion to allow circulation in the bloodstream a characteristic of cancer

Answer 16

yes

Question 17

is high fidelity replication that yields a stable genome a characteristic of cancer

Answer 17

no

Question 18

is immortalization by overexpression of caspases a characteristic of cancer

Answer 18

no

Question 19

a heritable change to DNA that cannot be corrected is a

Answer 19

mutagen

Question 20

cancer is also known as

Answer 20

malignant neoplasia

Question 21

steroids that increase the rat of cell division are a class of

Answer 21

tumor promoter

Question 22

______ can activate the intrinsic apoptosis pathway

Answer 22

DNA Damage

Question 23

which are the products of proto-oncogenes and tumor suppressor genes

Answer 23

PO products: P2,P3
TSG Products: P1, P4

Question 24

which are protien products of genes that require a minimum of 2 genomic mutations to yield a phenotypic change

Answer 24

P1, P4

Question 25

which could be a protein product of a DNA tumor virus infection

Answer 25

P2